Thorell K, Muñoz-Ramírez ZY, Wang D, Sandoval-Motta S, Boscolo Agostini R, Ghirotto S, Torres RC, Romero-Gallo J, Krishna U, Peek RM, Piazuelo MB, Raaf N, Bentolila F, Aftab H, Akada J, Matsumoto T, Haesebrouck F, Colanzi RP, Bartelli TF, Nunes DN, Pelosof A, Sztokfisz CZ, Dias-Neto E, Assumpção PP, Tishkov I, Mabeku LBK, Goodman KJ, Geary J, Cromarty TJ, Price NL, Quilty D, Corvalan AH, Serrano CA, Gonzalez R, Riquelme A, García-Cancino A, Parra-Sepúlveda C, Bernal G, Castillo F, Goldstein AM, Hu N, Taylor PR, Bravo MM, Pazos A, Bravo LE, Wilson KT, Fox JG, Ramírez-Mayorga V, Molina-Castro S, Durán-Bermúdez S, Campos-Núñez C, Chaves-Cervantes M, Tshibangu-Kabamba E, Tumba GD, Tshimpi-Wola A, de Jesus Ngoma-Kisoko P, Ngoyi DM, Cruz M, Hosking C, Abreu JJ, Varon C, Benejat L, Secka O, Link A, Malfertheiner P, Adinortey MB, Bockarie AS, Adinortey CA, Ofori EG, Sgouras DN, Martinez-Gonzalez B, Michopoulos S, Georgopoulos S, Hernandez E, Tacatic BV, Aguilar M, Dominguez RL, Morgan DR, Harðardóttir H, Gunnarsdóttir AI, Guðjónsson H, Jónasson JG, Björnsson ES, Ballal M, Shetty V, Miftahussurur M, Sugihartono T, Alfaray RI, Waskito LA, Fauzia KA, Syam AF, Maulahela H, Malekzadeh R, Sotoudeh M, Peretz A, Azrad M, On A, De Re V, Zanussi S, Cannizzaro R, Canzonieri V, Shimura T, Tokunaga K, Osaki T, Kamiya S, Jadallah K, Matalka I, Igissinov N, Moldobaeva MS, Rakhat A, Choi IJ, Kim JG, Kim N, Song M, Leja M, Vangravs R, Šķenders Ģ, Rudzīte D, Rūdule A, Vanags A, Kikuste I, Kupcinskas J, Skieceviciene J, Jonaitis L, Kiudelis G, Jonaitis P, Kiudelis V, Varkalaite G, Vadivelu J, Loke MF, Vellasamy KM, Herrera-Goepfert R, Alonso-Larraga JO, Yee TT, Htet K, Matsuhisa T, Shrestha PK, Ansari S, Abiodun O, Jemilohun C, Akande KO, Olu-Abiodun O, Magaji FA, Omotoso A, Osuagwu CC, Okonkwo U, Owoseni OO, Castaneda C, Castillo M, Velapatino B, Gilman RH, Krzyżek P, Gościniak G, Pawełka D, Korona-Glowniak I, Cichoz-Lach H, Oleastro M, Figueiredo C, Machado JC, Ferreira RM, Bordin DS, Livzan MA, Tsukanov VV, Tan P, Yeoh KG, Zhu F, Ally R, Haas R, Montes M, Fernández-Reyes M, Tamayo E, Lizasoain J, Bujanda L, Lario S, Ramírez-Lázaro MJ, Calvet X, Brunet-Mas E, Domper-Arnal MJ, García-Mateo S, Abad-Baroja D, Delgado-Guillena P, Moreira L, Botargues J, Pérez-Martínez I, Barreiro-Alonso E, Flores V, Gisbert JP, Muro EA, Linares P, Martin V, Alcoba L, Fleitas-Kanonnikoff T, Altayeb HN, Engstrand L, Enroth H, Keller PM, Wagner K, Pohl D, Lee YC, Liou JM, Wu MS, Kocazeybek B, Sarıbas S, Tasçı İ, Demiryas S, Kepil N, Quiel L, Villagra M, Norton M, Johnson D, Huang RJ, Hwang JH, Szymczak W, Rajagopalan S, Asare E, Jacobs WR, In H, Bollag R, Lopez A, Kruse EJ, White J, Graham DY, Lane C, Gao Y, Fields PI, Gold BD, Cruz-Correa M, González-Pons M, Rodriguez LM, Tuan VP, Dung HDQ, Binh TT, Trang TTH, Van Khien V, Chen X, Raley C, Kessing B, Zhao Y, Tran B, Gutiérrez-Escobar AJ, Wan Y, Hicks B, Zhu B, Yu K, Zhu B, Yeager M, Hutchinson A, Teshome K, Jones K, Luo W, Jehanne Q, Katsura Y, Gonzalez-Hormazabal P, Didelot X, Sheppard S, Tarazona-Santos E, Mariño-Ramírez L, Loh JT, Backert S, Naumann M, Abnet CC, Smet A, Berg DE, Chiner-Oms Á, Comas I, Martínez-Martínez FJ, Zamudio R, Lehours P, Megraud F, Yahara K, Blaser MJ, Vincze T, Morgan RD, Roberts RJ, Chanock SJ, Dekker JP, Torres J, Cover TL, Noureen M, Fischer W, Vale FF, Cherry JL, Osada N, Fukuyo M, Arita M, Yamaoka Y, Kobayashi I, Uchiyama I, Falush D, Camargo MC, Rabkin CS (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 14
Article Number: 8184
Journal Issue: 1
DOI: 10.1038/s41467-023-43562-y
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics.
APA:
Thorell, K., Muñoz-Ramírez, Z.Y., Wang, D., Sandoval-Motta, S., Boscolo Agostini, R., Ghirotto, S.,... Rabkin, C.S. (2023). The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes. Nature Communications, 14(1). https://dx.doi.org/10.1038/s41467-023-43562-y
MLA:
Thorell, Kaisa, et al. "The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes." Nature Communications 14.1 (2023).
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