Combined continuous nanoparticle synthesis with chromatographic size classification

Gromotka L, Biegel M, Damm C, Traore N, Drobek D, Spiecker E, Peukert W (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Advanced Powder Technology Elsevier

Book Volume: 35

Article Number: 104294

Journal Issue: 1

DOI: 10.1016/j.apt.2023.104294

Abstract

In this paper, we report a combination of the continuous flow synthesis of gold nanoparticles (AuNPs) with subsequent purification and narrowing of the particle size distribution (PSD) by size-exclusion chromatography (SEC) by adapting the flow rates of synthesis and classification. First, we show scalability of chromatographic classification with respect to column dimension and the absence of irreversible nanoparticle adhesion on the column material. Two different syntheses lead to a large and widely distributed and a small and narrowly distributed AuNP dispersion, which are classified by a semipreparative column. The PSDs of individual fractions are characterized by analytical SEC. The broadly distributed AuNP dispersion was classified into three fractions with distinct PSDs. For the narrowly distributed AuNPs, the separation is almost independent of the mobile phase flow rate: coarse and fine fractions with almost identical PSDs and separation efficiency curves are observed irrespective of the flow rate. Even NP samples with narrow PSDs can be classified into multiple fractions with tailored PSDs while simultaneously removing dissolved impurities from the dispersion. With our study, we demonstrate the potential of a direct combination of continuous NP synthesis with chromatographic classification for the optimization of final PSDs and the simultaneous purification of nanoparticulate dispersions.

Authors with CRIS profile

Lukas Hartmann Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Markus Biegel Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Cornelia Damm Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Nabi Traore Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Dominik Drobek Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung) Erdmann Spiecker Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung) Wolfgang Peukert Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik

How to cite

APA:

Gromotka, L., Biegel, M., Damm, C., Traore, N., Drobek, D., Spiecker, E., & Peukert, W. (2024). Combined continuous nanoparticle synthesis with chromatographic size classification. Advanced Powder Technology, 35(1). https://dx.doi.org/10.1016/j.apt.2023.104294

MLA:

Gromotka, Lukas, et al. "Combined continuous nanoparticle synthesis with chromatographic size classification." Advanced Powder Technology 35.1 (2024).

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