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Virtual Heart Models Help Elucidate the Role of Border Zone in Sustained Monomorphic Ventricular Tachycardia

Castaneda Gavina E, Suzuki M, Ashikaga H, Lluch È, Meister F, Mihalef V, Audigier C, Maier A, Halperin H, Passerini T (2023)

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Publication Type: Conference contribution

Publication year: 2023

Journal

Publisher: Springer Science and Business Media Deutschland GmbH

Book Volume: 14226 LNCS

Pages Range: 216-225

Conference Proceedings Title: Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Event location: Vancouver, BC, CAN

ISBN: 9783031439896

DOI: 10.1007/978-3-031-43990-2_21

Abstract

Post-ischemic Ventricular Tachycardia (VT) is sustained by a depolarization wave re-entry through channel-like structures within the post-ischemic scar. These structures are usually formed by partially viable tissue, called Border Zone (BZ). Understanding the anatomical and electrical properties of the BZ is crucial to guide ablation therapy to the right targets, reducing the likelihood of VT recurrence. Virtual Heart methods can provide ablation guidance non-invasively, but they have high computational complexity and have shown limited capability to accurately reproduce the specific mechanisms responsible for clinically observed VT. These outstanding challenges undermine the utility of Virtual Hearts for high precision ablation guidance in clinical practice. In this work, fast phenomenological models are developed to efficiently and accurately simulate the re-entrant dynamics of VT as observed in 12-lead ECG. Two porcine models of Myocardial Infarction (MI) are used to generate personalized bi-ventricular models from pre-operative LGE-MRI images. Myocardial conductivity and action potential duration are estimated using sinus rhythm ECG measurements. Multiple hypotheses for the BZ tissue properties are tested, and optimal values are identified. These allow the Virtual Heart model to produce VTs with good agreements with measurements in terms of ECG lead polarity and VT cycle length. Efficient GPU implementation of the cardiac electrophysiology model allows computation of sustained monomorphic VT in times compatible with the clinical workflow.

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How to cite

APA:

Castaneda Gavina, E., Suzuki, M., Ashikaga, H., Lluch, È., Meister, F., Mihalef, V.,... Passerini, T. (2023). Virtual Heart Models Help Elucidate the Role of Border Zone in Sustained Monomorphic Ventricular Tachycardia. In Hayit Greenspan, Hayit Greenspan, Anant Madabhushi, Parvin Mousavi, Septimiu Salcudean, James Duncan, Tanveer Syeda-Mahmood, Russell Taylor (Eds.), Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (pp. 216-225). Vancouver, BC, CAN: Springer Science and Business Media Deutschland GmbH.

MLA:

Castaneda Gavina, Eduardo, et al. "Virtual Heart Models Help Elucidate the Role of Border Zone in Sustained Monomorphic Ventricular Tachycardia." Proceedings of the 26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023, Vancouver, BC, CAN Ed. Hayit Greenspan, Hayit Greenspan, Anant Madabhushi, Parvin Mousavi, Septimiu Salcudean, James Duncan, Tanveer Syeda-Mahmood, Russell Taylor, Springer Science and Business Media Deutschland GmbH, 2023. 216-225.

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