High-throughput imaging across multiple spatial scales with the multi-camera array microscope (MCAM)

Kreiß L, Zhou K, Kim K, Harfouche M, Xu S, Jönsson J, Lee KC, Cook C, Yang X, Reamey P, Saliu V, Horstmeyer G, Horstmeyer R (2023)

Publication Type: Conference contribution

Publication year: 2023

Publisher: SPIE

Book Volume: 12622

Conference Proceedings Title: Proceedings of SPIE - The International Society for Optical Engineering

Event location: Munich DE

ISBN: 9781510664531

DOI: 10.1117/12.2675451

Abstract

“Anyone who uses a microscope has likely noticed the limitation of the trade-off between the field of view and the resolution”.1 To acquire highly resolved images at large fields of view, existing techniques typically record sequential images at different positions and then digitally stitch composite images. There are alternatives to this mechanical scanning procedure, such as structured illumination microscopy2 or Fourier ptychography3,4 that record sequential images at varying illuminations prevent mechanical scanning for high-resolution image composites. However, all of these approaches require sequential images and thus compromise speed, temporal resolution and experimental throughput. Here we present the Multi-Camera Array Microscope (MCAM), which is a microscope system that utilizes an array of many synchronized cameras, each with an individual imaging lens, for simultaneous image capture. The MCAM enables enhanced imaging capabilities and novel applications in various scientific and medical fields, by combining the images acquired from each individual camera-lens pair.

Authors with CRIS profile

Lucas Kreiß Lehrstuhl für Medizinische Biotechnologie

Involved external institutions

Duke University US United States (USA) (US)

How to cite

APA:

Kreiß, L., Zhou, K., Kim, K., Harfouche, M., Xu, S., Jönsson, J.,... Horstmeyer, R. (2023). High-throughput imaging across multiple spatial scales with the multi-camera array microscope (MCAM). In Pietro Ferraro, Demetri Psaltis, Simonetta Grilli (Eds.), Proceedings of SPIE - The International Society for Optical Engineering. Munich, DE: SPIE.

MLA:

Kreiß, Lucas, et al. "High-throughput imaging across multiple spatial scales with the multi-camera array microscope (MCAM)." Proceedings of the Optical Methods for Inspection, Characterization, and Imaging of Biomaterials VI 2023, Munich Ed. Pietro Ferraro, Demetri Psaltis, Simonetta Grilli, SPIE, 2023.

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