Iron oxide nanoparticle-based nanocomposites in biomedical application

Yang Y, Liu Y, Song L, Cui X, Zhou J, Jin G, Boccaccini AR, Virtanen S (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

DOI: 10.1016/j.tibtech.2023.06.001

Abstract

Iron-oxide-based biomagnetic nanocomposites, recognized for their significant properties, have been utilized in MRI and cancer treatment for several decades. The expansion of clinical applications is limited by the occurrence of adverse effects. These limitations are largely attributed to suboptimal material design, resulting in agglomeration, reduced magnetic relaxivity, and inadequate functionality. To address these challenges, various synthesis methods and modification strategies have been used to tailor the size, shape, and properties of iron oxide nanoparticle (FeONP)-based nanocomposites. The resulting modified nanocomposites exhibit significant potential for application in diagnostic, therapeutic, and theranostic contexts, including MRI, drug delivery, and anticancer and antimicrobial activity. Yet, their biosafety profile must be rigorously evaluated. Such efforts will facilitate the broader clinical translation of FeONP-based nanocomposites in biomedical applications.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Sannakaisa Virtanen Professur für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Involved external institutions

Harbin Engineering University (HEU) / 哈尔滨工程大学

China (CN) State University of New York at Albany (UNY Albany / UAlbany)

United States (USA) (US)

How to cite

APA:

Yang, Y., Liu, Y., Song, L., Cui, X., Zhou, J., Jin, G.,... Virtanen, S. (2023). Iron oxide nanoparticle-based nanocomposites in biomedical application. Trends in Biotechnology. https://doi.org/10.1016/j.tibtech.2023.06.001

MLA:

Yang, Yuyun, et al. "Iron oxide nanoparticle-based nanocomposites in biomedical application." Trends in Biotechnology (2023).

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