The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila
Frasch M, Ismat A, Reim I, Raufer J (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 150
Journal Issue: 18
DOI: 10.1242/dev.201457
Abstract
Development of the visceral musculature of the Drosophila midgut encompasses a closely coordinated sequence of migration events of cells from the trunk and caudal visceral mesoderm that underlies the formation of the stereotypic orthogonal pattern of circular and longitudinal midgut muscles. Our study focuses on the last step of migration and morphogenesis of longitudinal visceral muscle precursors and shows that these multinucleated precursors utilize dynamic filopodial extensions to migrate in dorsal and ventral directions over the forming midgut tube. The establishment of maximal dorsoventral distances from one another, and anteroposterior alignments, lead to the equidistant coverage of the midgut with longitudinal muscle fibers. We identify Teyrha-Meyhra (Tey), a tissue-specific nuclear factor related to the RNF220 domain protein family, as a crucial regulator of this process of muscle migration and morphogenesis that is further required for proper differentiation of longitudinal visceral muscles. In addition, Tey is expressed in a single somatic muscle founder cell in each hemisegment, regulates the migration of this founder cell, and is required for proper pathfinding of its developing myotube to specific myotendinous attachment sites.
Authors with CRIS profile
Manfred Frasch
Department Biologie
Ingolf Reim
Naturwissenschaftliche Fakultät
Jasmin Raufer
Lehrstuhl für Entwicklungsbiologie
Involved external institutions
United States (USA) (US)How to cite
APA:
Frasch, M., Ismat, A., Reim, I., & Raufer, J. (2023). The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila. Development, 150(18). https://dx.doi.org/10.1242/dev.201457
MLA:
Frasch, Manfred, et al. "The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila." Development 150.18 (2023).
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