Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
Xu Z, Keller E, Beltrán AM, Zheng K, Boccaccini AR (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 620
Article Number: 122578
DOI: 10.1016/j.jnoncrysol.2023.122578
Abstract
Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible post-impregnation approach to incorporate metallic ions (Ca and Ce) into dendritic mesoporous silica nanoparticles, resulting in SiO2-CaO and SiO2-CaO-CeO2 (Ce-DMBGNs) without destroying the dendritic mesoporous topography. Both DMBGNs and Ce-DMBGNs were amorphous, negatively charged, with a hydrodynamic size of ∼200 nm. The synthesized DMBGNs and Ce-DMBGNs exhibited high bioactivity as evidenced by the rapid formation of hydroxyapatite (HA) after immersion in simulated body fluid (SBF) for 7 days. In addition, DMBGNs and Ce-DMBGNs showed high propolis loading efficiency and sustained release behavior. The results suggest that the developed Ce-DMBGNs have the potential to be used as a delivery vehicle of therapeutic ions and drugs in bone regeneration applications.
Authors with CRIS profile
Zhiyan Xu
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
Nanjing Medical University / 南京医科大学
China (CN)
University of Seville / Universidad de Sevilla
Spain (ES)
China (CN)
University of Seville / Universidad de Sevilla
Spain (ES)
How to cite
APA:
Xu, Z., Keller, E., Beltrán, A.M., Zheng, K., & Boccaccini, A.R. (2023). Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability. Journal of Non-Crystalline Solids, 620. https://dx.doi.org/10.1016/j.jnoncrysol.2023.122578
MLA:
Xu, Zhiyan, et al. "Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability." Journal of Non-Crystalline Solids 620 (2023).
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