Evaluation of Gas 6 as a Prognostic Marker in Papillary Renal Cell Carcinoma

Mikuteit M, Zschäbitz S, Stoehr C, Herrmann E, Polifka I, Agaimy A, Trojan L, Ströbel P, Becker F, Wülfing C, Barth P, Stöckle M, Staehler M, Stief C, Haferkamp A, Hohenfellner M, Duensing S, Macher-Göppinger S, Wullich B, Noldus J, Brenner W, Roos F, Walter B, Otto W, Burger M, Erlmeier M, Schrader AJ, Hartmann A, Erlmeier F, Steffens S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1159/000529898

Abstract

Introduction: Growth arrest-specific protein 6 (Gas 6) is a ligand that plays a role in proliferation and migration of cells. For several tumor entities, high levels of Gas 6 are associated with poorer survival. We examined the prognostic role of Gas 6 in renal cell carcinoma (RCC), especially in papillary RCC (pRCC), which is still unclear. Methods: The patients' sample collection is a joint collaboration of the PANZAR consortium. Patients' medical history and tumor specimens were collected from n = 240 and n = 128 patients with type 1 and 2 pRCC, respectively. Expression of Gas 6 was determined by immunohistochemistry. Results: In total, Gas 6 staining was evaluable in 180 of 240 type 1 and 110 of 128 type 2 pRCC cases. Kaplan-Meier analysis disclosed no significant difference in 5-year overall survival for all pRCC nor either subtype. Also, Gas+ and Gas- groups did not significantly differ in any tumor or patient characteristics. Conclusion: Gas 6 was not found to be an independent prognostic marker in pRCC. Future studies are warranted to determine if Gas 6 plays a role as prognostic marker or therapeutic target in pRCC.

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Involved external institutions

München Klinik Bogenhausen Germany (DE) Universitätsmedizin der Johannes Gutenberg-Universität Mainz Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) Germany (DE) Universitätsklinikum Münster Germany (DE) St. Elisabeth Gruppe GmbH - Katholische Kliniken Rhein-Ruhr Germany (DE) Universitätsklinikum Göttingen Germany (DE) Universität Regensburg Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Klinikum der Universität München Germany (DE) Philipps-Universität Marburg Germany (DE)

How to cite

APA:

Mikuteit, M., Zschäbitz, S., Stoehr, C., Herrmann, E., Polifka, I., Agaimy, A.,... Steffens, S. (2023). Evaluation of Gas 6 as a Prognostic Marker in Papillary Renal Cell Carcinoma. Urologia Internationalis. https://doi.org/10.1159/000529898

MLA:

Mikuteit, Marie, et al. "Evaluation of Gas 6 as a Prognostic Marker in Papillary Renal Cell Carcinoma." Urologia Internationalis (2023).

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