Lindemann A, Roth D, Koop K, Neufert C, Zundler S, Atreya R, Neurath M, Leppkes M (2023)
Publication Type: Journal article
Publication year: 2023
Book Volume: 10
Article Number: 1177450
DOI: 10.3389/fmed.2023.1177450
Background and aims: Acute severe steroid-refractory ulcerative colitis remains a medically challenging condition with frequent need of surgery. It can be treated with the calcineurin inhibitor cyclosporine A with the need for therapeutic drug monitoring and significant toxicity. Recently, a novel calcineurin inhibitor, voclosporin, has been approved for the treatment of lupus nephritis with no need for therapeutic drug monitoring and an improved long-term safety profile. However, the therapeutic effect of voclosporin in acute severe steroid-refractory ulcerative colitis is still uncertain. We aimed to assess the therapeutic potential of voclosporin to ameliorate inflammation in an experimental model of colitis. Methods: We used the dextran sodium sulfate-induced model of colitis in C57BL/6 J wildtype mice treated with either cyclosporine A, voclosporin or solvent control. We employed endoscopy, histochemistry, immunofluorescence, bead-based multiplex immunoassays and flow cytometry to study the therapeutic effect of calcineurin inhibitors in a preventive setting. Results: Acute colitis was induced by dextran sodium sulfate characterized by weight loss, diarrhea, mucosal erosions and rectal bleeding. Both cyclosporine A and voclosporin strongly ameliorated the course of disease and reduced colitis severity in a similar manner. Conclusion: Voclosporin was identified as biologically effective in a preclinical model of colitis and may be a potential therapeutic option in treating acute severe steroid-refractory ulcerative colitis.
APA:
Lindemann, A., Roth, D., Koop, K., Neufert, C., Zundler, S., Atreya, R.,... Leppkes, M. (2023). Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis. Frontiers in Medicine, 10. https://doi.org/10.3389/fmed.2023.1177450
MLA:
Lindemann, Aylin, et al. "Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis." Frontiers in Medicine 10 (2023).
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