Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

Sui B, Xu Z, Xue Z, Xiang Y, Zhou T, Beltrán AM, Zheng K, Liu X, Boccaccini AR (2023)

Publication Type: Journal article

Publication year: 2023

Journal

ACS Applied Materials and Interfaces American Chemical Society

DOI: 10.1021/acsami.3c03680

Abstract

Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.

Authors with CRIS profile

Zhiyan Xu Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Shanghai Ninth People's Hospital (Bethel Hospital) CN China (CN) University of Electronic Science and Technology of China (UESTC) / 电子科技大学 CN China (CN) University of Seville / Universidad de Sevilla ES Spain (ES) Nanjing Medical University / 南京医科大学 CN China (CN)

How to cite

APA:

Sui, B., Xu, Z., Xue, Z., Xiang, Y., Zhou, T., Beltrán, A.M.,... Boccaccini, A.R. (2023). Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity. ACS Applied Materials and Interfaces. https://dx.doi.org/10.1021/acsami.3c03680

MLA:

Sui, Baiyan, et al. "Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity." ACS Applied Materials and Interfaces (2023).

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