Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres

Aguilar Rabiela AE, Homaeigohar S, González-Castillo EI, Sanchez M, Boccaccini AR (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Polymers MDPI

Book Volume: 15

Article Number: 2432

Journal Issue: 11

DOI: 10.3390/polym15112432

Abstract

In recent years, composite biomaterials have attracted attention for drug delivery applications due to the possibility of combining desired properties of their components. However, some functional characteristics, such as their drug release efficiency and likely side effects, are still unexplored. In this regard, controlled tuning of the drug release kinetic via the precise design of a composite particle system is still of high importance for many biomedical applications. This objective can be properly fulfilled through the combination of different biomaterials with unequal release rates, such as mesoporous bioactive glass nanoparticles (MBGN) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres. In this work, MBGNs and PHBV-MBGN microspheres, both loaded with Astaxanthin (ASX), were synthesised and compared in terms of ASX release kinetic, ASX entrapment efficiency, and cell viability. Moreover, the correlation of the release kinetic to phytotherapeutic efficiency and side effects was established. Interestingly, there were significant differences between the ASX release kinetic of the developed systems, and cell viability differed accordingly after 72 h. Both particle carriers effectively delivered ASX, though the composite microspheres exhibited a more prolonged release profile with sustained cytocompatibility. The release behaviour could be fine-tuned by adjusting the MBGN content in the composite particles. Comparatively, the composite particles induced a different release effect, implying their potential for sustained drug delivery applications.

Authors with CRIS profile

Arturo Elias Aguilar Rabiela Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Mirna Sanchez Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Dundee GB United Kingdom (GB) Polymer Institute / Ústav Polymérov SK Slovakia (SK)

How to cite

APA:

Aguilar Rabiela, A.E., Homaeigohar, S., González-Castillo, E.I., Sanchez, M., & Boccaccini, A.R. (2023). Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres. Polymers, 15(11). https://dx.doi.org/10.3390/polym15112432

MLA:

Aguilar Rabiela, Arturo Elias, et al. "Comparison between the Astaxanthin Release Profile of Mesoporous Bioactive Glass Nanoparticles (MBGNs) and Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/MBGN Composite Microspheres." Polymers 15.11 (2023).

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