Sox9 regulates melanocytic fate decision of adult hair follicle stem cells

Stüfchen I, Beyer F, Stäbler S, Fischer S, Kappelmann M, Beckervordersandforth R, Boßerhoff AK (2023)

Publication Type: Journal article

Publication year: 2023

Journal

iScience Elsevier

Book Volume: 26

Article Number: 106919

Journal Issue: 6

DOI: 10.1016/j.isci.2023.106919

Abstract

The bulge of hair follicles harbors Nestin+ (neural crest like) stem cells, which exhibit the potential to generate various cell types including melanocytes. In this study, we aimed to determine the role of Sox9, an important regulator during neural crest development, in melanocytic differentiation of those adult Nestin+ cells. Immunohistochemical analysis after conditional Sox9 deletion in Nestin+ cells of adult mice revealed that Sox9 is crucial for melanocytic differentiation of these cells and that Sox9 acts as a fate determinant between melanocytic and glial fate. A deeper understanding of factors that regulate fate decision, proliferation and differentiation of these stem cells provides new aspects to melanoma research as melanoma cells share many similarities with neural crest cells. In summary, we here show the important role of Sox9 in melanocytic versus glial fate decision of Nestin+ stem cells in the skin of adult mice.

Authors with CRIS profile

Isabel Stüfchen Lehrstuhl für Biochemie und Molekulare Medizin Felix Beyer Lehrstuhl für Biochemie und Molekulare Medizin Sebastian Stäbler Lehrstuhl für Biochemie und Molekulare Medizin Melanie Kappelmann-Fenzl Emil-Fischer-Zentrum (Emil Fischer Center) Ruth Beckervordersandforth-Bonk Lehrstuhl für Biochemie und Pathobiochemie Anja Katrin Boßerhoff Lehrstuhl für Biochemie und Molekulare Medizin

Additional Organisation(s)

Sonderforschungsbereich 1540: Erforschung der Mechanik des Gehirns (EBM): Verständnis, Engineering und Nutzung mechanischer Eigenschaften und Signale in der Entwicklung, Physiologie und Pathologie des zentralen Nervensystems

Related research project(s)

D038: Impact of the transcriptional regulator AP2e on melanoma development and progression March 16, 2023 - Sept. 15, 2025

Involved external institutions

Technische Hochschule Deggendorf DE Germany (DE)

How to cite

APA:

Stüfchen, I., Beyer, F., Stäbler, S., Fischer, S., Kappelmann, M., Beckervordersandforth, R., & Boßerhoff, A.K. (2023). Sox9 regulates melanocytic fate decision of adult hair follicle stem cells. iScience, 26(6). https://doi.org/10.1016/j.isci.2023.106919

MLA:

Stüfchen, Isabel, et al. "Sox9 regulates melanocytic fate decision of adult hair follicle stem cells." iScience 26.6 (2023).

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