A 3D-Printed Wound-Healing Material Composed of Alginate Dialdehyde-Gelatin Incorporating Astaxanthin and Borate Bioactive Glass Microparticles

Monavari M, Homaeigohar S, Medhekar RS, Nawaz Q, Monavari M, Zheng K, Boccaccini AR (2023)

Publication Type: Journal article

Publication year: 2023

Journal

DOI: 10.1021/acsami.2c23252

Abstract

In this study, a wound dressing composed of an alginate dialdehyde-gelatin (ADA-GEL) hydrogel incorporated by astaxanthin (ASX) and 70B (70:30 B2O3/CaO in mol %) borate bioactive glass (BBG) microparticles was developed through 3D printing. ASX and BBG particles stiffened the composite hydrogel construct and delayed its in vitro degradation compared to the pristine hydrogel construct, mainly due to their cross-linking role, likely arising from hydrogen bonding between the ASX/BBG particles and ADA-GEL chains. Additionally, the composite hydrogel construct could hold and deliver ASX steadily. The composite hydrogel constructs codelivered biologically active ions (Ca and B) and ASX, which should lead to a faster, more effective wound-healing process. As shown through in vitro tests, the ASXcontaining composite hydrogel promoted fibroblast (NIH 3T3) cell adhesion, proliferation, and vascular endothelial growth factor expression, as well as keratinocyte (HaCaT) migration, thanks to the antioxidant activity of ASX, the release of cell-supportive Ca2+ and B3+ ions, and the biocompatibility of ADA-GEL. Taken together, the results show that the ADA-GEL/BBG/ASX composite is an attractive biomaterial to develop multipurposed wound-healing constructs through 3D printing.

Authors with CRIS profile

Involved external institutions

University of Dundee United Kingdom (GB) Nanjing Medical University / 南京医科大学 China (CN) Federal Institute For Materials Research and Testing Germany (DE)

How to cite

APA:

Monavari, M., Homaeigohar, S., Medhekar, R.S., Nawaz, Q., Monavari, M., Zheng, K., & Boccaccini, A.R. (2023). A 3D-Printed Wound-Healing Material Composed of Alginate Dialdehyde-Gelatin Incorporating Astaxanthin and Borate Bioactive Glass Microparticles. ACS Applied Materials and Interfaces. https://doi.org/10.1021/acsami.2c23252

MLA:

Monavari, Mahshid, et al. "A 3D-Printed Wound-Healing Material Composed of Alginate Dialdehyde-Gelatin Incorporating Astaxanthin and Borate Bioactive Glass Microparticles." ACS Applied Materials and Interfaces (2023).

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