Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler C, Monavari M, Abraham GA, Boccaccini AR, Ghorbani F (2023)

Publication Type: Journal article

Publication year: 2023

Journal

RSC Advances Royal Society of Chemistry

Book Volume: 13

Pages Range: 15960-15974

Journal Issue: 23

DOI: 10.1039/d3ra01311a

Abstract

This study seeks to simulate both the chemistry and piezoelectricity of bone by synthesizing electroconductive silane-modified gelatin-poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) scaffolds using the freeze drying technique. In order to enhance hydrophilicity, cell interaction, and biomineralization, the scaffolds were functionalized with polydopamine (PDA) inspired by mussels. Physicochemical, electrical, and mechanical analyses were conducted on the scaffolds, as well as in vitro evaluations using the osteosarcoma cell line MG-63. It was found that scaffolds had interconnected porous structures, so the PDA layer formation reduced the size of pores while maintaining scaffold uniformity. PDA functionalization reduced the electrical resistance of the constructs while improving their hydrophilicity, compressive strength, and modulus. As a result of the PDA functionalization and the use of silane coupling agents, higher stability and durability were achieved as well as an improvement in biomineralization capability after being soaked in SBF solution for a month. Additionally, the PDA coating enabled the constructs to enhance viability, adhesion, and proliferation of MG-63 cells, as well as to express alkaline phosphatase and deposit HA, indicating that scaffolds can be used for bone regeneration. Therefore, the PDA-coated scaffolds developed in this study and the non-toxic performance of PEDOT:PSS present a promising approach for further in vitro and in vivo studies.

Authors with CRIS profile

Mahshid Monavari Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Farnaz Ghorbani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

National University of Mar del Plata / Universidad Nacional de Mar del Plata (UNMdP) AR Argentina (AR)

How to cite

APA:

Adler, C., Monavari, M., Abraham, G.A., Boccaccini, A.R., & Ghorbani, F. (2023). Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration. RSC Advances, 13(23), 15960-15974. https://dx.doi.org/10.1039/d3ra01311a

MLA:

Adler, Catalina, et al. "Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration." RSC Advances 13.23 (2023): 15960-15974.

BibTeX: Download