Functionalisation of Graphene Sensor Surfaces for the Specific Detection of Biomarkers

Von Lueders L, Tilmann R, Lee K, Bartlam C, Stimpel-Lindner T, Nevanen TK, Iljin K, Knirsch K, Hirsch A, Duesberg GS (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Angewandte Chemie International Edition Wiley

Book Volume: 62

Article Number: e202219024

Journal Issue: 22

DOI: 10.1002/anie.202219024

Abstract

We report on a controllable and specific functionalisation route for graphene field-effect transistors (GFETs) for the recognition of small physiologically active molecules. Key element is the noncovalent functionalisation of the graphene surface with perylene bisimide (PBI) molecules directly on the growth substrate. This Functional Layer Transfer enables the homogeneous self-assembly of PBI molecules on graphene, onto which antibodies are subsequently immobilised. The sensor surface was characterised by atomic force microscopy, Raman spectroscopy and electrical measurements, showing superior performance over conventional functionalisation after transfer. Specific sensing of small molecules was realised by monitoring the electrical property changes of functionalised GFET devices upon the application of methamphetamine and cortisol. The concentration dependent electrical response of our sensors was determined down to a concentration of 300 ng ml−1 for methamphetamine.

Authors with CRIS profile

Kathrin Knirsch Lehrstuhl für Organische Chemie II Andreas Hirsch Lehrstuhl für Organische Chemie II

Involved external institutions

Universität der Bundeswehr München DE Germany (DE) VTT Technical Research Centre of Finland FI Finland (FI)

How to cite

APA:

Von Lueders, L., Tilmann, R., Lee, K., Bartlam, C., Stimpel-Lindner, T., Nevanen, T.K.,... Duesberg, G.S. (2023). Functionalisation of Graphene Sensor Surfaces for the Specific Detection of Biomarkers. Angewandte Chemie International Edition, 62(22). https://doi.org/10.1002/anie.202219024

MLA:

Von Lueders, Laura, et al. "Functionalisation of Graphene Sensor Surfaces for the Specific Detection of Biomarkers." Angewandte Chemie International Edition 62.22 (2023).

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