Electrophoretic deposition of coatings for local delivery of therapeutic agents

Cheng X, Liu Y, Liu O, Lu Y, Liao Z, Hadzhieva Z, Chen L, Leeuwenburgh SG, Boccaccini AR, Yang F (2023)

Publication Type: Journal article, Review article

Publication year: 2023

Journal

Progress in Materials Science Elsevier

Book Volume: 136

Article Number: 101111

DOI: 10.1016/j.pmatsci.2023.101111

Abstract

Electrophoretic deposition (EPD) is an effective technique to construct coatings onto the surface of medical devices. These coatings can act as reservoirs for local delivery of therapeutic agents, including metal ions and metal-free drugs. This manuscript presents a comprehensive overview of the fundamentals and application of EPD coatings for local delivery of therapeutic agents, with a specific focus on the mechanism and control over loading and release of therapeutic agents. After a brief introduction of the EPD coating process, the matrices that are most commonly deposited using EPD for drug delivery purposes are summarized including the mechanism of their deposition without additives and co-deposition with additives. Subsequently, three strategies towards loading therapeutic agents are discussed, including i) co-deposition of therapeutic agents with coating matrices, ii) pre-loading therapeutic agents into microcarriers, and iii) post-loading therapeutic agents into prepared coatings. Furthermore, factors influencing loading (e.g., EPD processing parameters and additives) are identified. Subsequently, the release mechanisms as well as the influence of both intrinsic (e.g., additives, layered structures, building blocks, and microcarrier properties) and extrinsic processing parameters (e.g., pH, electric, magnetic and photothermal stimuli) used to tune the release kinetics are presented. Additionally, the applications of therapeutic agent loaded EPD coatings are summarized. Finally, the remaining challenges and future perspectives related to the use of EPD coatings for drug delivery purposes are reviewed.

Authors with CRIS profile

Zoya Hadzhieva Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Central South University CN China (CN) Tongji Medical College (TJMC) / 同济医学院 CN China (CN) Radboud University Nijmegen Medical Centre / Radboudumc of voluit Radboud Universitair Medisch Centrum (UMC) NL Netherlands (NL)

How to cite

APA:

Cheng, X., Liu, Y., Liu, O., Lu, Y., Liao, Z., Hadzhieva, Z.,... Yang, F. (2023). Electrophoretic deposition of coatings for local delivery of therapeutic agents. Progress in Materials Science, 136. https://dx.doi.org/10.1016/j.pmatsci.2023.101111

MLA:

Cheng, Xian, et al. "Electrophoretic deposition of coatings for local delivery of therapeutic agents." Progress in Materials Science 136 (2023).

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