In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs
Bellmann T, Thamm J, Beekmann U, Kralisch D, Fischer D (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 15
Article Number: 559
Journal Issue: 2
DOI: 10.3390/pharmaceutics15020559
Abstract
Bacterial nanocellulose has been widely investigated in drug delivery, but the incorporation of lipophilic drugs and controlling release kinetics still remain a challenge. The inclusion of polymer particles to encapsulate drugs could address both problems but is reported sparely. In the present study, a formulation approach based on in situ precipitation of poly(lactic-co-glycolic acid) within bacterial nanocellulose was developed using and comparing the conventional solvent N-methyl-2-pyrrolidone and the alternative solvents poly(ethylene glycol), CyreneTM and ethyl lactate. Using the best-performing solvents N-methyl-2-pyrrolidone and ethyl lactate, their fast diffusion during phase inversion led to the formation of homogenously distributed polymer microparticles with average diameters between 2.0 and 6.6 µm within the cellulose matrix. Despite polymer inclusion, the water absorption value of the material still remained at ~50% of the original value and the material was able to release 32 g/100 cm2 of the bound water. Mechanical characteristics were not impaired compared to the native material. The process was suitable for encapsulating the highly lipophilic drugs cannabidiol and 3-O-acetyl-11-keto-β-boswellic acid and enabled their sustained release with zero order kinetics over up to 10 days. Conclusively, controlled drug release for highly lipophilic compounds within bacterial nanocellulose could be achieved using sustainable solvents for preparation.
Authors with CRIS profile
Tom Bellmann
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Dagmar Fischer
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Bellmann, T., Thamm, J., Beekmann, U., Kralisch, D., & Fischer, D. (2023). In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs. Pharmaceutics, 15(2). https://dx.doi.org/10.3390/pharmaceutics15020559
MLA:
Bellmann, Tom, et al. "In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs." Pharmaceutics 15.2 (2023).
BibTeX: Download