Effekt von additivem körperlichem Training zur Bisphosphonat-Therapie auf die Knochendichte: Eine systematische Übersichtsarbeit und Meta-Analyse

Klotz C, Jakob F, Kohl M, von Stengel S, Lange U, Thomasius F, Kerschan-Schindl K, Uder M, Kemmler W (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Book Volume: 31

Pages Range: 184-194

Journal Issue: 3

DOI: 10.1055/a-1904-5706

Abstract

Background Physical exercise and antiresorptive pharmacological therapy affect bone metabolism through different mechanisms. The present study addresses the question of whether bisphosphonate treatment with additional exercise training has additive effects on bone density (BMD) at the lumbar spine (LS) and/or femoral neck (SH). Methods Our systematic literature search of five electronic databases according to PRISMA included controlled trials with a duration of≥6 months with at least two study arms: (a) bisphosphonates (B), (b) bisphosphonates and exercise (B+E) published up to 26 August 2021. Studies including other pharmaceutical therapies or diseases with relevant effects on bone metabolism were excluded. The analysis was conducted as a random-effects meta-analysis. Outcome measures were standardized mean differences (SMD) for BMD changes at LS and SH. Results Our search identified four eligible studies with a total of 247 participants. In summary, compared with bisphosphonate therapy alone, the combined intervention did not demonstrate significantly higher effect sizes at LS- (SMD: 0.66, 95%-CI: - 0.63 to 1.94) or SH-BMD (0.49, - 0.42 to 1.40). We observed very high heterogeneity among the results of the included studies for both, BMD-LWS and BMD-SH (I 2: 89 and 92%, respectively). The evidence for a small study or publication bias is also quite high for both outcomes. Conclusion We could not detect a significantly superior effect of a combined intervention (B+E) compared to isolated bisphosphonate therapy on BMD at LS and/or SH. However, the eligible studies indicate a high heterogeneity, which we primarily refer to the different training protocols of the trials.

Authors with CRIS profile

Involved external institutions

Kerckhoff-Klinik Germany (DE) Frankfurter Hormon und Osteoporosezentrum Germany (DE) Julius-Maximilians-Universität Würzburg Germany (DE) Universität Wien / University of Vienna Austria (AT) Hochschule Furtwangen Germany (DE)

How to cite

APA:

Klotz, C., Jakob, F., Kohl, M., von Stengel, S., Lange, U., Thomasius, F.,... Kemmler, W. (2022). Effekt von additivem körperlichem Training zur Bisphosphonat-Therapie auf die Knochendichte: Eine systematische Übersichtsarbeit und Meta-Analyse. Osteologie, 31(3), 184-194. https://doi.org/10.1055/a-1904-5706

MLA:

Klotz, Christopher, et al. "Effekt von additivem körperlichem Training zur Bisphosphonat-Therapie auf die Knochendichte: Eine systematische Übersichtsarbeit und Meta-Analyse." Osteologie 31.3 (2022): 184-194.

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