A20 as a Potential New Tool in Predicting Recurrence and Patient’s Survival in Oral Squamous Cell Carcinoma

Spoerl S, Erber R, Gerken M, Taxis J, Ludwig N, Nieberle F, Biermann N, Geppert CI, Ettl T, Hartmann A, Beckhove P, Reichert TE, Spanier G, Spörl S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Book Volume: 15

Article Number: 675

Journal Issue: 3

DOI: 10.3390/cancers15030675

Abstract

A20, known as a potent inhibitor of NF-κB signaling, has been characterized in numerous clinical as well as preclinical studies. Recently, especially in various malignant diseases, the prognostic and therapeutic relevance of A20 was investigated. In oral squamous cell carcinoma (OSCC) however, the characterization of A20 is uncharted territory. We analyzed a tissue microarray (TMA) of 229 surgically-treated OSCC patients (2003–2013). Immunohistochemical (IHC) stainings were performed for A20 and CD3; additionally, standard haematoxylin-eosin staining was applied. IHC findings were correlated with a comprehensive dataset, comprising clinical and pathohistological information. A20 expression was analyzed in tumor cells as well as in tumor infiltrating lymphocytes (TILs) and correlated with the overall survival (OS) and recurrence-free survival (RFS) using uni- and multivariable Cox regression. The median follow-up time was 10.9 years and the A20 expression was significantly decreased in CD3+ TILs compared to mucosa-infiltrating lymphocytes (MILs). In the Kaplan–Meier analyses, higher A20 expression in TILs was correlated with better OS (p = 0.017) and RFS (p = 0.020). In the multivariable survival analysis, A20 overexpression correlated with improved OS (HR: 0.582; 95% CI 0.388–0.873, p = 0.009) and RFS (HR 0.605; 95% CI 0.411–0.889, p = 0.011). Our results indicate a novel prognostic role for A20 in OSCC. Due to its elevated expression in TILs, further research is highly desirable, which therefore could offer new therapeutic opportunities for patients suffering from OSCC.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Regensburg Germany (DE) Universität Regensburg Germany (DE) Leibniz-Institut für Immuntherapie (LIT) / Leibniz Institute for Immunotherapy Germany (DE)

How to cite

APA:

Spoerl, S., Erber, R., Gerken, M., Taxis, J., Ludwig, N., Nieberle, F.,... Spörl, S. (2023). A20 as a Potential New Tool in Predicting Recurrence and Patient’s Survival in Oral Squamous Cell Carcinoma. Cancers, 15(3). https://dx.doi.org/10.3390/cancers15030675

MLA:

Spoerl, Steffen, et al. "A20 as a Potential New Tool in Predicting Recurrence and Patient’s Survival in Oral Squamous Cell Carcinoma." Cancers 15.3 (2023).

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