Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu
Xu Z, Qi X, Bao M, Zhou T, Shi J, Xu Z, Zhou M, Boccaccini AR, Zheng K, Jiang X (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 25
Pages Range: 239-255
DOI: 10.1016/j.bioactmat.2023.01.024
Abstract
Type II diabetes mellitus (TIIDM) remains a challenging clinical issue for both dentists and orthopedists. By virtue of persistent hyperglycemia and altered host metabolism, the pathologic diabetic micromilieu with chronic inflammation, advanced glycation end products accumulation, and attenuated biomineralization severely impairs bone regeneration efficiency. Aiming to “remodel” the pathologic diabetic micromilieu, we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles (Sr-MBGNs) and gelatin methacrylate (GelMA). Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr, Ca, and Si ions enhancing osteogenic, angiogenic, and immunomodulatory properties. In addition to angiogenic and anti-inflammatory outcomes, this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen, promoting cell focal adhesion, modulating osteoblast differentiation, and boosting the release of OCN, the noncollagenous proteins (intrafibrillar mineralization dependent), and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN axis. This 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the “barren” diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.
Authors with CRIS profile
Zhiyan Xu
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Aldo Boccaccini
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Involved external institutions
China (CN)How to cite
APA:
Xu, Z., Qi, X., Bao, M., Zhou, T., Shi, J., Xu, Z.,... Jiang, X. (2023). Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu. Bioactive Materials, 25, 239-255. https://dx.doi.org/10.1016/j.bioactmat.2023.01.024
MLA:
Xu, Zeqian, et al. "Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu." Bioactive Materials 25 (2023): 239-255.
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