Inflammaging and Blood Pressure Profiles in Late Life: The Screening for CKD among Older People across Europe (SCOPE) Study
Tap L, Corsonello A, Di Rosa M, Fabbietti P, Formiga F, Moreno-Gonzalez R, Arnlov J, Carlsson AC, Polinder-Bos HA, Roller-Wirnsberger RE, Wirnsberger GH, Kostka T, Guligowska A, Artzi-Medvedik R, Yehoshua I, Weingart C, Sieber C, Gil P, Lainez Martinez S, Lattanzio F, Mattace-Raso FUS (2022)
Publication Type: Journal article, Original article
Publication year: 2022
Journal
Book Volume: 11
Journal Issue: 24
DOI: 10.3390/jcm11247311
Open Access Link: https://www.mdpi.com/1996622
Abstract
The neutrophil-to-lymphocyte ratio (NLR) is a marker for systemic inflammation. Since inflammation plays a relevant role in vascular aging, the aim of this study was to investigate whether NLR is associated with blood pressure profiles in older adults. This study was performed within the framework of the SCOPE study including 2461 outpatients aged 75 years and over. Mean blood pressure values, namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were investigated across tertiles of NLR. Change in blood pressure levels in 2 years of follow-up were compared across categories of baseline NLR. Data of 2397 individuals were used, of which 1854 individuals had hypertension. Mean values of blood pressure did not differ across categories of baseline NLR in individuals without hypertension. Individuals with hypertension with a high-range NLR had lower SBP and PP when compared to those in low-range NLR (mean difference SBP -2.94 mmHg, p = 0.032 and PP -2.55 mmHg, p = 0.030). Mean change in blood pressure in 2 years did only slightly differ in non-clinically relevant ranges, when compared across tertiles of baseline NLR. NLR as a marker of inflammaging was not associated with unfavorable blood pressure profiles in older individuals with or without hypertension.
Authors with CRIS profile
Involved external institutions
Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA)
Italy (IT)
Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב
Israel (IL)
Dalarna University College
Sweden (SE)
Karolinska Institute
Sweden (SE)
Medical University of Łódź / Uniwersytet Medyczny w Łodzi
Poland (PL)
Maccabi Healthcare
Israel (IL)
Hospital Clínico San Carlos
Spain (ES)
Erasmus University Medical Center (MC)
Netherlands (NL)
Bellvitge University Hospital / Hospital Universitari de Bellvitge
Spain (ES)
Italy (IT)
Ben-Gurion University of the Negev (BGU) / אוניברסיטת בן-גוריון בנגב
Israel (IL)
Dalarna University College
Sweden (SE)
Karolinska Institute
Sweden (SE)
Medical University of Łódź / Uniwersytet Medyczny w Łodzi
Poland (PL)
Maccabi Healthcare
Israel (IL)
Hospital Clínico San Carlos
Spain (ES)
Erasmus University Medical Center (MC)
Netherlands (NL)
Bellvitge University Hospital / Hospital Universitari de Bellvitge
Spain (ES)
How to cite
APA:
Tap, L., Corsonello, A., Di Rosa, M., Fabbietti, P., Formiga, F., Moreno-Gonzalez, R.,... Mattace-Raso, F.U.S. (2022). Inflammaging and Blood Pressure Profiles in Late Life: The Screening for CKD among Older People across Europe (SCOPE) Study. Journal of Clinical Medicine, 11(24). https://dx.doi.org/10.3390/jcm11247311
MLA:
Tap, Lisanne, et al. "Inflammaging and Blood Pressure Profiles in Late Life: The Screening for CKD among Older People across Europe (SCOPE) Study." Journal of Clinical Medicine 11.24 (2022).
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