Structural analysis of DNA molecule in a confined shell
Maity A, Mathur N, Imhof P, Singh N (2023)
Publication Type: Journal article
Publication year: 2023
Journal
Book Volume: 609
DOI: 10.1016/j.physa.2022.128382
Abstract
Recent advances in operating and manipulating DNA have provided unique experimental possibilities in many fields of DNA research, especially in gene therapy. Researchers have deployed many techniques, experimental and theoretical, to study the DNA structure changes due to external perturbation. It is crucial to understand the structural and dy-namical changes in the DNA molecules in a confined state to understand and control the self-assembly of DNA confined in a chamber or nano-channel for various applications. In the current manuscript, we extend the work study the effect of confinement on the thermal stability and the structural properties of duplex DNA. The present work is an extension of our previous research works (Maity et al., 2019; 2020). For our study we have considered a 1 BNA chain that is confined in a cylindrical geometry. How the geometry of the confinement affects the opening and other structural parameters of DNA molecule is the objective of this manuscript. We have used a statistical model(PBD model) and Molecular dynamics simulations for our purpose. (c) 2022 Elsevier B.V. All rights reserved.
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APA:
Maity, A., Mathur, N., Imhof, P., & Singh, N. (2023). Structural analysis of DNA molecule in a confined shell. Physica A-Statistical Mechanics and Its Applications, 609. https://dx.doi.org/10.1016/j.physa.2022.128382
MLA:
Maity, Arghya, et al. "Structural analysis of DNA molecule in a confined shell." Physica A-Statistical Mechanics and Its Applications 609 (2023).
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