In vivo evaluation of B-TCP containing 3D laser sintered poly(ether ether ketone) composites in pigs
von Wilmowsky C, Lutz R, Meisel U, Srour S, Rupprecht S, Toyoshima T, Nkenke E, Schlegel KA, Pohle D, Münstedt H, Rechtenwald T, Schmidt M (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 24
Pages Range: 169-184
Journal Issue: 2
Abstract
The aim of this study was to produce an individually shaped medical implant from a 3D database and to evaluate the biological behavior of a laser sintered poly(ether ether ketone) (PEEK) implant with incorporated osteoconductive bone materials in porcine bone defects. Laser sintered PEEK samples containing ß-tricalciumphosphate (ß-TCP) were implanted into critical size defects in the frontal skull of ten pigs. Compression moulded pure PEEK was used as a reference material. The bone-implant interface was histomorphometrically analysed after 6, 12, and 24 weeks. Histomorphometrical evaluations after 24 weeks revealed that the superficially located ß-TCP was in contact with the surrounding bone, whereas the other groups were fibrous encapsulated. Interfacial shear strength was significantly higher for the ß-TCP containing group in comparison to the compression moulded PEEK group (p = 0.004) and the laser sintered PEEK group. The laser sintered PEEK implants seem to be attractive as bone substitutes for reconstructive surgery due to their individually constructed 3D shape and biocompatibility. © 2009 SAGE Publications.
Authors with CRIS profile
Cornelius von Wilmowsky
Medizinische Fakultät
Rainer Lutz
Department of Oral and Cranio-Maxillofacial Surgery
Stephan Rupprecht
Medizinische Fakultät
Helmut Münstedt
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Michael Schmidt
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
von Wilmowsky, C., Lutz, R., Meisel, U., Srour, S., Rupprecht, S., Toyoshima, T.,... Schmidt, M. (2009). In vivo evaluation of B-TCP containing 3D laser sintered poly(ether ether ketone) composites in pigs. Journal of Bioactive and Compatible Polymers, 24(2), 169-184. https://dx.doi.org/10.1177/0883911508101149
MLA:
von Wilmowsky, Cornelius, et al. "In vivo evaluation of B-TCP containing 3D laser sintered poly(ether ether ketone) composites in pigs." Journal of Bioactive and Compatible Polymers 24.2 (2009): 169-184.
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