The CAM Model—Q&A with Experts
Fischer D, Fluegen G, Garcia P, Ghaffari-Tabrizi-Wizsy N, Gribaldo L, Huang RYJ, Rasche V, Ribatti D, Rousset X, Pinto MT, Viallet J, Wang Y, Schneider-Stock R (2023)
Publication Type: Journal article, Review article
Publication year: 2023
Journal
Book Volume: 15
Article Number: 191
Journal Issue: 1
Abstract
The chick chorioallantoic membrane (CAM), as an extraembryonic tissue layer generated by the fusion of the chorion with the vascularized allantoic membrane, is easily accessible for manipulation. Indeed, grafting tumor cells on the CAM lets xenografts/ovografts develop in a few days for further investigations. Thus, the CAM model represents an alternative test system that is a simple, fast, and low-cost tool to study tumor growth, drug response, or angiogenesis in vivo. Recently, a new era for the CAM model in immune-oncology-based drug discovery has been opened up. Although there are many advantages offering extraordinary and unique applications in cancer research, it has also disadvantages and limitations. This review will discuss the pros and cons with experts in the field.
Authors with CRIS profile
Dagmar Fischer
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie
Regine Schneider-Stock
Professur für Experimentelle Tumorpathologie
Involved external institutions
Universitätsklinikum Düsseldorf
Germany (DE)
University of Grenoble Alpes (UGA) / Université de Grenoble
France (FR)
Medizinische Universität Graz
Austria (AT)
European Commission - Joint Research Centre (JRC)
Netherlands (NL)
National Taiwan University (NTU) / 國立臺灣大學
Taiwan (TW)
Universitätsklinikum Ulm
Germany (DE)
University of Bari Aldo Moro / Università degli Studi di Bari Aldo Moro
Italy (IT)
Universidade do Porto
Portugal (PT)
Germany (DE)
University of Grenoble Alpes (UGA) / Université de Grenoble
France (FR)
Medizinische Universität Graz
Austria (AT)
European Commission - Joint Research Centre (JRC)
Netherlands (NL)
National Taiwan University (NTU) / 國立臺灣大學
Taiwan (TW)
Universitätsklinikum Ulm
Germany (DE)
University of Bari Aldo Moro / Università degli Studi di Bari Aldo Moro
Italy (IT)
Universidade do Porto
Portugal (PT)
How to cite
APA:
Fischer, D., Fluegen, G., Garcia, P., Ghaffari-Tabrizi-Wizsy, N., Gribaldo, L., Huang, R.Y.J.,... Schneider-Stock, R. (2023). The CAM Model—Q&A with Experts. Cancers, 15(1). https://dx.doi.org/10.3390/cancers15010191
MLA:
Fischer, Dagmar, et al. "The CAM Model—Q&A with Experts." Cancers 15.1 (2023).
BibTeX: Download