Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia

Loris E, Ollenschläger M, Greinwalder T, Eskofier B, Winkler J, Gaßner H, Regensburger M (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Annals of Clinical and Translational Neurology Wiley

Book Volume: 10

Journal Issue: 3

DOI: 10.1002/acn3.51725

Open Access Link: https://doi.org/10.1186/s13023-023-02854-8

Abstract

Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter-individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conjunction with clinical and patient-reported outcome parameters. Our cohort included adult HSP patients (n = 55) with up to 77 months of follow-up. Gait speed showed a significant association with SPRS progression. Changes in stride time and gait variability correlated to fear of falling and quality of life, providing evidence that gait parameters are meaningful measures of HSP progression.

Authors with CRIS profile

Malte Ollenschläger Department of Molecular Neurology Björn Eskofier Machine Learning and Data Analytics Lab Jürgen Winkler Professur für Molekulare Neurologie Heiko Gaßner Department of Molecular Neurology Martin Regensburger Medizinische Fakultät

How to cite

APA:

Loris, E., Ollenschläger, M., Greinwalder, T., Eskofier, B., Winkler, J., Gaßner, H., & Regensburger, M. (2023). Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia. Annals of Clinical and Translational Neurology, 10(3). https://dx.doi.org/10.1002/acn3.51725

MLA:

Loris, Evelyn, et al. "Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia." Annals of Clinical and Translational Neurology 10.3 (2023).

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