Impact of solvent properties on the precipitation of active pharmaceutical ingredients

Schikarski T, Trzenschiok H, Avila M, Peukert W (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Powder Technology Elsevier

Book Volume: 415

Article Number: 118032

DOI: 10.1016/j.powtec.2022.118032

Abstract

In antisolvent precipitation, water and an organic drug-containing solvent induces particle formation. For each water-solvent mixture, the fluid properties such as viscosity, density and diffusion coefficient but also the drug solubility depend nonlinearily on the fluid mixture compositions. Each property in itself has a strong impact on the solid formation, and thus on the outcome of the precipitation. The simulation framework recently developed by Schikarski et al. [1] allows investigating separately the impact of each fluid property on the precipitation. For a T-mixer and a novel 3-inlet-mixer, we first show that the viscosity and density variations largely determine the macroscopic mixing behavior and, thus, the build-up of supersaturation. The composition-dependent diffusion properties of the drug molecules largely govern the transport-controlled nucleation and particle growth at small scales. In a second step, we numerically predict the experimentally obtained full particle size distribution of the precipitated Ibuprofen nanoparticles using different water-solvent mixtures and different operating conditions. Our numerical results are in excellent agreement with our experimental measurements using ethanol, methanol and 2-propanol as solvents.

Authors with CRIS profile

Tobias Schikarski Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Holger Trzenschiok Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik Wolfgang Peukert Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik

Involved external institutions

Universität Bremen DE Germany (DE)

How to cite

APA:

Schikarski, T., Trzenschiok, H., Avila, M., & Peukert, W. (2023). Impact of solvent properties on the precipitation of active pharmaceutical ingredients. Powder Technology, 415. https://dx.doi.org/10.1016/j.powtec.2022.118032

MLA:

Schikarski, Tobias, et al. "Impact of solvent properties on the precipitation of active pharmaceutical ingredients." Powder Technology 415 (2023).

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