Metal Oxide Nanoparticles: Review of Synthesis, Characterization and Biological Effects

Negrescu AM, Killian MS, Raghu SNV, Schmuki P, Mazare AV, Cimpean A (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Journal of Functional Biomaterials MDPI

Book Volume: 13

Journal Issue: 4

DOI: 10.3390/jfb13040274

Abstract

In the last few years, the progress made in the field of nanotechnology has allowed researchers to develop and synthesize nanosized materials with unique physicochemical characteristics, suitable for various biomedical applications. Amongst these nanomaterials, metal oxide nanoparticles (MONPs) have gained increasing interest due to their excellent properties, which to a great extent differ from their bulk counterpart. However, despite such positive advantages, a substantial body of literature reports on their cytotoxic effects, which are directly correlated to the nanoparticles' physicochemical properties, therefore, better control over the synthetic parameters will not only lead to favorable surface characteristics but may also increase biocompatibility and consequently lower cytotoxicity. Taking into consideration the enormous biomedical potential of MONPs, the present review will discuss the most recent developments in this field referring mainly to synthesis methods, physical and chemical characterization and biological effects, including the pro-regenerative and antitumor potentials as well as antibacterial activity. Moreover, the last section of the review will tackle the pressing issue of the toxic effects of MONPs on various tissues/organs and cell lines.

Authors with CRIS profile

Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) Anca Valentina Mazare Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Involved external institutions

Universität Siegen DE Germany (DE) University of Bucharest / Universitatea din București RO Romania (RO)

How to cite

APA:

Negrescu, A.M., Killian, M.S., Raghu, S.N.V., Schmuki, P., Mazare, A.V., & Cimpean, A. (2022). Metal Oxide Nanoparticles: Review of Synthesis, Characterization and Biological Effects. Journal of Functional Biomaterials, 13(4). https://dx.doi.org/10.3390/jfb13040274

MLA:

Negrescu, Andreea Mariana, et al. "Metal Oxide Nanoparticles: Review of Synthesis, Characterization and Biological Effects." Journal of Functional Biomaterials 13.4 (2022).

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