Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials

Weizel A, Distler T, Detsch R, Boccaccini AR, Seitz H, Budday S (2023)

Publication Type: Journal article

Publication year: 2023

Journal

Journal of the Mechanical Behavior of Biomedical Materials Elsevier

Book Volume: 138

Article Number: 105618

DOI: 10.1016/j.jmbbm.2022.105618

Abstract

Numerical simulations are a valuable tool to understand which processes during mechanical stimulations of hydrogels for cartilage replacement influence the behavior of chondrocytes and contribute to the success or failure of these materials as implants. Such simulations critically rely on the correct prediction of the material response through appropriate material models and corresponding parameters. In this study, we identify hyper-viscoelastic material parameters for numerical simulations in COMSOL Multiphysics® v. 5.6 for human articular cartilage and two replacement materials, the commercially available ChondroFiller^liquid and oxidized alginate gelatin (ADA-GEL) hydrogels. We incorporate the realistic experimental boundary conditions into an inverse parameter identification scheme based on data from multiple loading modes simultaneously, including cyclic compression-tension and stress relaxation experiments. We provide individual parameter sets for the unconditioned and conditioned responses and discuss how viscoelastic effects are related to the materials’ microstructure. ADA-GEL and ChondroFiller^liquid exhibit faster stress relaxation than cartilage with lower relaxation time constants, while cartilage has the largest viscoelastic stress contribution. The elastic response predominates in ADA-GEL and ChondroFiller^liquid, while the viscoelastic response predominates in cartilage. These results will help to simulate mechanical stimulations, support the development of suitable materials with distinct mechanical properties in the future and provide parameters and insight into the time-dependent material behavior of human articular cartilage.

Authors with CRIS profile

Thomas Distler Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Silvia Budday Lehrstuhl für Technische Mechanik

Involved external institutions

Universität Rostock

Germany (DE)

How to cite

APA:

Weizel, A., Distler, T., Detsch, R., Boccaccini, A.R., Seitz, H., & Budday, S. (2023). Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials. Journal of the Mechanical Behavior of Biomedical Materials, 138. https://dx.doi.org/10.1016/j.jmbbm.2022.105618

MLA:

Weizel, A., et al. "Time-dependent hyper-viscoelastic parameter identification of human articular cartilage and substitute materials." Journal of the Mechanical Behavior of Biomedical Materials 138 (2023).

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