Fabrication and assessment of bifunctional electrospun poly(L-lactic acid) scaffolds with bioglass and zinc oxide nanoparticles for bone tissue engineering

Canales DA, Piñones N, Saavedra M, Loyo C, Palza H, Peponi L, Leonés A, Baier RV, Boccaccini AR, Grünewald A, Zapata PA (2023)

Publication Type: Journal article

Publication year: 2023

Journal

International Journal of Biological Macromolecules Elsevier

Book Volume: 228

Pages Range: 78-88

DOI: 10.1016/j.ijbiomac.2022.12.195

Abstract

Electrospun scaffolds based on poly(L-lactic acid) (PLLA) with bioglass (n-BG) and zinc oxide (n-ZnO), and mixture of both, were developed to design bifunctional biomaterials with enhanced bioactive and biocidal properties. The presence of n-BG increased the fiber diameter of the pure PLA from 1.5 ± 0.3 μm to 3.0 ± 0.8 μm for 20 wt%. ZnO and the mixed nanoparticles did not significantly affect the morphology. The mechanical properties decreased with the presence of nanoparticles. Scaffolds based on PLA/n-BG promoted hydroxyapatite (HA) formation in simulated body fluid (SBF) that was inhibited with the presence of ZnO. Notably, mixed particles produced bioactivity although at longer times. The incorporation of n-ZnO produced a biocidal capacity against S. aureus in the polymeric scaffold, reaching a viability reduction of 60 % after 6 h of exposure. When both types of nanoparticles were combined, the bacterial viability reduction was 30 %. Pure PLA scaffolds and the composites with n-BG showed good ST-2 bone marrow-derived cell line viability, scaffolds with n-BG (pure or mixture) presented lower viability. Results validated the use of both n-BG and n-ZnO fillers for the development of novel bifunctional PLA-based scaffolds with both bioactive and biocidal properties for bone tissue engineering applications.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Alina Grünewald Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC) ES Spain (ES) Universidad de Chile CL Chile (CL) Universidad de Santiago de Chile (USACH) / University of Santiago, Chile CL Chile (CL)

How to cite

APA:

Canales, D.A., Piñones, N., Saavedra, M., Loyo, C., Palza, H., Peponi, L.,... Zapata, P.A. (2023). Fabrication and assessment of bifunctional electrospun poly(L-lactic acid) scaffolds with bioglass and zinc oxide nanoparticles for bone tissue engineering. International Journal of Biological Macromolecules, 228, 78-88. https://dx.doi.org/10.1016/j.ijbiomac.2022.12.195

MLA:

Canales, Daniel A., et al. "Fabrication and assessment of bifunctional electrospun poly(L-lactic acid) scaffolds with bioglass and zinc oxide nanoparticles for bone tissue engineering." International Journal of Biological Macromolecules 228 (2023): 78-88.

BibTeX: Download