A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19

Singh J, Herrmann I, Mahajan A, Schauer C, Shan X, Hartmann A, Rieker R, Evert K, Falkeis C, Naschberger E, von Stillfried S, Boor P, Munoz LE, Schett G, Herrmann M, Knopf J (2022)

Publication Type: Journal article

Publication year: 2022

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 23

Article Number: 15126

Journal Issue: 23

DOI: 10.3390/ijms232315126

Abstract

Vascular occlusions in patients with coronavirus diseases 2019 (COVID-19) have been frequently reported in severe outcomes mainly due to a dysregulation of neutrophils mediating neutrophil extracellular trap (NET) formation. Lung specimens from patients with COVID-19 have previously shown a dynamic morphology, categorized into three types of pleomorphic occurrence based on histological findings in this study. These vascular occlusions in lung specimens were also detected using native endogenous fluorescence or NEF in a label-free method. The three types of vascular occlusions exhibit morphology of DNA rich neutrophil elastase (NE) poor (type I), NE rich DNA poor (type II), and DNA and NE rich (type III) cohort of eleven patients with six males and five females. Age and gender have been presented in this study as influencing variables linking the occurrence of several occlusions with pleomorphic contents within a patient specimen and amongst them. This study reports the categorization of pleomorphic occlusions in patients with COVID-19 and the detection of these occlusions in a label-free method utilizing NEF.

Authors with CRIS profile

Jeeshan Singh Department of Medicine 3 – Rheumatology and Immunology Aparna Mahajan Department of Medicine 3 – Rheumatology and Immunology Christine Schauer Department of Medicine 3 – Rheumatology and Immunology Xiaomei Shan Lehrstuhl für Innere Medizin III Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Ralf Rieker Institute of Pathology Elisabeth Naschberger Department of Surgery Luis Munoz Becerra Department of Medicine 3 – Rheumatology and Immunology Georg Schett Lehrstuhl für Innere Medizin III Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology Jasmin Knopf Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Klinikum Bayreuth DE Germany (DE) Universitätsklinikum Aachen (UKA) DE Germany (DE) Universität Regensburg DE Germany (DE)

How to cite

APA:

Singh, J., Herrmann, I., Mahajan, A., Schauer, C., Shan, X., Hartmann, A.,... Knopf, J. (2022). A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19. International Journal of Molecular Sciences, 23(23). https://dx.doi.org/10.3390/ijms232315126

MLA:

Singh, Jeeshan, et al. "A Pleomorphic Puzzle: Heterogeneous Pulmonary Vascular Occlusions in Patients with COVID-19." International Journal of Molecular Sciences 23.23 (2022).

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