Surface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using Antibodies

Gabel M, Knauß A, Fischer D, Neurath M, Weigmann B (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 23

Article Number: 13929

Journal Issue: 22

DOI: 10.3390/ijms232213929

Abstract

The mechanism of RNA interference (RNAi) could represent a breakthrough in the therapy of all diseases that arise from a gene defect or require the inhibition of a specific gene expression. In particular, small interfering RNA (siRNA) offers an attractive opportunity to achieve a new milestone in the therapy of human diseases. The limitations of siRNA, such as poor stability, inefficient cell uptake, and undesired immune activation, as well as the inability to specifically reach the target tissue in the body, can be overcome by further developments in the field of nanoparticulate drug delivery. Therefore, types of surface modified siRNA nanoparticles are presented and illustrate how a more efficient and safer distribution of siRNA at the target site is possible by modifying the surface properties of nanoparticles with antibodies. However, the development of such efficient and safe delivery strategies is currently still a major challenge. In consideration of that, this review article aims to demonstrate the function and targeted delivery of siRNA nanoparticles, focusing on the surface modification via antibodies, various lipid- and polymer-components, and the therapeutic effects of these delivery systems.

Authors with CRIS profile

Michael Gabel Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Annkathrin Knauß Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Dagmar Fischer Lehrstuhl für Pharmazeutische Technologie und Biopharmazie Markus Neurath Lehrstuhl für Innere Medizin I Benno Weigmann Medizinische Fakultät

How to cite

APA:

Gabel, M., Knauß, A., Fischer, D., Neurath, M., & Weigmann, B. (2022). Surface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using Antibodies. International Journal of Molecular Sciences, 23(22). https://dx.doi.org/10.3390/ijms232213929

MLA:

Gabel, Michael, et al. "Surface Design Options in Polymer- and Lipid-Based siRNA Nanoparticles Using Antibodies." International Journal of Molecular Sciences 23.22 (2022).

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