The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective

Lai X, Schmitz U, Vera J (2022)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2022

Journal

Advances in Experimental Medicine and Biology Kluwer Academic Publishers

Publisher: Springer

Series: Advances in Experimental Medicine and Biology

Book Volume: 1385

Pages Range: 1-22

DOI: 10.1007/978-3-031-08356-3_1

Abstract

Since the discovery of microRNAs (miRNAs) in Caenorhabditis elegans, our understanding of their cellular function has progressed continuously. Today, we have a good understanding of miRNA-mediated gene regulation, miRNA-mediated cross talk between genes including competing endogenous RNAs, and miRNA-mediated signaling transduction both in normal human physiology and in diseases. Besides, these noncoding RNAs have shown their value for clinical applications, especially in an oncological context. They can be used as reliable biomarkers for cancer diagnosis and prognosis and attract increasing attention as potential therapeutic targets. Many achievements made in the miRNA field are based on joint efforts from computational and molecular biologists. Systems biology approaches, which integrate computational and experimental methods, have played a fundamental role in uncovering the cellular functions of miRNAs. In this chapter, we review and discuss the role of miRNAs in oncology from a system biology perspective. We first describe biological facts about miRNA genetics and function. Next, we discuss the role of miRNAs in cancer progression and review the application of miRNAs in cancer diagnostics and therapy. Finally, we elaborate on the role that miRNAs play in cancer gene regulatory networks. Taken together, we emphasize the importance of systems biology approaches in our continued efforts to study miRNA cancer regulation.

Authors with CRIS profile

Xin Lai Department of Dermatology Julio Vera González Professur für Tumorimmunologie (Schwerpunkt Systembiologie)

Involved external institutions

James Cook University AU Australia (AU)

How to cite

APA:

Lai, X., Schmitz, U., & Vera, J. (2022). The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective. In (pp. 1-22). Springer.

MLA:

Lai, Xin, Ulf Schmitz, and Julio Vera. "The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective." Springer, 2022. 1-22.

BibTeX: Download