Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications

Nakiou EA, Lazaridou M, Pouroutzidou GK, Michopoulou A, Tsamesidis I, Liverani L, Arango Ospina M, Beketova A, Boccaccini AR, Kontonasaki E, Bikiaris DN (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Polymers MDPI

Book Volume: 14

Article Number: 5028

Journal Issue: 22

DOI: 10.3390/polym14225028

Abstract

Background: Aliphatic polyesters are widely used for biomedical, pharmaceutical and environmental applications due to their high biodegradability and cost-effective production. Recently, star and hyperbranched polyesters based on glycerol and ω-carboxy fatty diacids have gained considerable interest. Succinic acid and bio-based diacids similar to glycerol are regarded as safe materials according to the US Food and Drug Administration (FDA). Bioactive glass scaffolds utilized in bone tissue engineering are relatively brittle materials. However, their mechanical properties can be improved by using polymer coatings that can further control their degradation rate, tailor their biocompatibility and enhance their performance. The purpose of this study is to explore a new biopolyester poly(glycerol succinate) (PGSuc) reinforced with mesoporous bioactive nanoparticles (MSNs) as a novel coating material to produce hybrid scaffolds for bone tissue engineering. Methods: Bioactive glass scaffolds were coated with neat PGSuc, PGSuc loaded with dexamethasone sodium phosphate (DexSP) and PGSuc loaded with DexSP-laden MSNs. The physicochemical, mechanical and biological properties of the scaffolds were also evaluated. Results: Preliminary data are provided showing that polymer coatings with and without MSNs improved the physicochemical properties of the 1393 bioactive glass scaffolds and increased the ALP activity and alizarin red staining, suggesting osteogenic differentiation potential when cultured with adipose-derived mesenchymal stem cells. Conclusions: PGSuc with incorporated MSNs coated onto 1393 bioactive glass scaffolds could be promising candidates in bone tissue engineering applications.

Authors with CRIS profile

Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Marcela Arango Ospina Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Aristotle University of Thessaloniki GR Greece (GR) Biohellenika Biotechnology Company S.A. GR Greece (GR)

How to cite

APA:

Nakiou, E.A., Lazaridou, M., Pouroutzidou, G.K., Michopoulou, A., Tsamesidis, I., Liverani, L.,... Bikiaris, D.N. (2022). Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications. Polymers, 14(22). https://dx.doi.org/10.3390/polym14225028

MLA:

Nakiou, Eirini A., et al. "Poly(Glycerol Succinate) as Coating Material for 1393 Bioactive Glass Porous Scaffolds for Tissue Engineering Applications." Polymers 14.22 (2022).

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