Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma
Choudhari JK, Eberhardt M, Chatterjee T, Hohberger B, Vera J (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 15
Article Number: 348
Journal Issue: 1
DOI: 10.1186/s13104-022-06210-0
Abstract
Objective: Glaucoma is a chronic neurological disease that is associated with high intraocular pressure (IOP), causes gradual damage to retinal ganglion cells, and often culminates in vision loss. Recent research suggests that glaucoma is a complex multifactorial disease in which multiple interlinked genes and pathways play a role during onset and development. Also, differential availability of trace elements seems to play a role in glaucoma pathophysiology, although their mechanism of action is unknown. The aim of this work is to disseminate a web-based repository on interactions between trace elements and protein-coding genes linked to glaucoma pathophysiology. Results: In this study, we present Glaucoma-TrEl, a web database containing information about interactions between trace elements and protein-coding genes that are linked to glaucoma. In the database, we include interactions between 437 unique genes and eight trace elements. Our analysis found a large number of interactions between trace elements and protein-coding genes mutated or linked to the pathophysiology of glaucoma. We associated genes interacting with multiple trace elements to pathways known to play a role in glaucoma. The web-based platform provides an easy-to-use and interactive tool, which serves as an information hub facilitating future research work on trace elements in glaucoma.
Authors with CRIS profile
Martin Eberhardt
Department of Dermatology
Bettina Hohberger
Department of Ophthalmology
Julio Vera González
Professur für Tumorimmunologie (Schwerpunkt Systembiologie)
Involved external institutions
India (IN)How to cite
APA:
Choudhari, J.K., Eberhardt, M., Chatterjee, T., Hohberger, B., & Vera, J. (2022). Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma. BMC Research Notes, 15(1). https://dx.doi.org/10.1186/s13104-022-06210-0
MLA:
Choudhari, Jyoti Kant, et al. "Glaucoma-TrEl: A web-based interactive database to build evidence-based hypotheses on the role of trace elements in glaucoma." BMC Research Notes 15.1 (2022).
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