Potent anti-inflammatory activity of the lectin-like domain of TNF in joints

Pinto ACMD, Nunes RDM, Nogueira IA, Fischer B, Lucas R, Girao-Carmona VCC, De Oliveira VLS, Amaral FA, Schett G, Rocha FAC (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 13

Article Number: 1049368

DOI: 10.3389/fimmu.2022.1049368

Abstract

In view of the crucial role of tumor necrosis factor (TNF) in joint destruction, TNF inhibitors, including neutralizing anti-TNF antibodies and soluble TNF receptor constructs, are commonly used therapeutics for the treatment of arthropathies like rheumatoid arthritis (RA). However, not all patients achieve remission; moreover, there is a risk of increased susceptibility to infection with these agents. Spatially distinct from its receptor binding sites, TNF harbors a lectin-like domain, which exerts unique functions that can be mimicked by the 17 residue solnatide peptide. This domain binds to specific oligosaccharides such as N′N′-diacetylchitobiose and directly target the α subunit of the epithelial sodium channel. Solnatide was shown to have anti-inflammatory actions in acute lung injury and glomerulonephritis models. In this study, we evaluated whether the lectin-like domain of TNF can mitigate the development of immune-mediated arthritis in mice. In an antigen-induced arthritis model, solnatide reduced cell influx and release of pro-inflammatory mediators into the joints, associated with reduction in edema and tissue damage, as compared to controls indicating that TNF has anti-inflammatory effects in an acute model of joint inflammation via its lectin-like domain.

Authors with CRIS profile

Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Universidade Federal do Ceará (UCF) BR Brazil (BR) Augusta University US United States (USA) (US) Universidade Federal de Minas Gerais (UFMG) BR Brazil (BR)

How to cite

APA:

Pinto, A.C.M.D., Nunes, R.D.M., Nogueira, I.A., Fischer, B., Lucas, R., Girao-Carmona, V.C.C.,... Rocha, F.A.C. (2022). Potent anti-inflammatory activity of the lectin-like domain of TNF in joints. Frontiers in Immunology, 13. https://dx.doi.org/10.3389/fimmu.2022.1049368

MLA:

Pinto, Ana Carolina Matias Dinelly, et al. "Potent anti-inflammatory activity of the lectin-like domain of TNF in joints." Frontiers in Immunology 13 (2022).

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