Concordance Rate of Colposcopy in Detecting Cervical Intraepithelial Lesions
Stübs F, Dietl A, Behrens A, Adler W, Geppert CI, Hartmann A, Knöll A, Beckmann M, Mehlhorn G, Schulmeyer C, Gaß P, Koch MC (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 12
Journal Issue: 10
DOI: 10.3390/diagnostics12102436
Abstract
Background: The purpose of this research is to estimate the rate of concordance, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of colposcopy for high-grade squamous lesions and carcinomas (HSIL+). Methods: We conducted a retrospective study of colposcopies performed in the certified Dysplasia Unit in Erlangen between January 2015 and May 2022 (7.5 years). The colposcopic findings were correlated with biopsies obtained during examinations or surgery. Cases without histology were excluded. The primary outcome was the rate of concordance between the colposcopic and histological findings in relation to the type of transformation zone (TZ), examiner's level of experience and age of the patients. Results: A total of 4778 colposcopies in 4001 women were analyzed. The rates of concordance for CIN I/LSIL, CIN II/HSIL, CIN III/HSIL, and carcinoma were 43.4%, 59.5%, 78.5%, and 53.9%, respectively. The rate of concordance was lowest for TZ3 and highest for colposcopists with more than 10 years' experience. Conclusions: Colposcopy is an important, feasible, and effective method. Careful work-up needs to be performed for women with TZ3 who are over 35 years old, as they are at the highest risk of being misdiagnosed. The highest concordance for detecting HSIL+ was seen for colposcopists with >10 years' experience.
Authors with CRIS profile
Frederik Stübs
Department of Obstetrics and Gynaecology
Anna Dietl
Department of Obstetrics and Gynaecology
Annika Behrens
Department of Obstetrics and Gynaecology
Werner Adler
Lehrstuhl für Biometrie und Epidemiologie
Carol-Immanuel Geppert
Institute of Pathology
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Antje Knöll
Institute of Clinical and Molecular Virology
Matthias Beckmann
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Carla Schulmeyer
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Paul Gaß
Department of Obstetrics and Gynaecology
Involved external institutions
Germany (DE)How to cite
APA:
Stübs, F., Dietl, A., Behrens, A., Adler, W., Geppert, C.-I., Hartmann, A.,... Koch, M.C. (2022). Concordance Rate of Colposcopy in Detecting Cervical Intraepithelial Lesions. Diagnostics, 12(10). https://dx.doi.org/10.3390/diagnostics12102436
MLA:
Stübs, Frederik, et al. "Concordance Rate of Colposcopy in Detecting Cervical Intraepithelial Lesions." Diagnostics 12.10 (2022).
BibTeX: Download