Systems Medicine Approach for Tinnitus with Comorbid Disorders
Mazurek B, Rose M, Schulze H, Dobel C (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 14
Article Number: 4320
Journal Issue: 20
DOI: 10.3390/nu14204320
Abstract
Despite the fact that chronic diseases usually occur together with a spectrum of possible comorbidities that may differ strongly between patients, they are classically still viewed as distinct disease entities and, consequently, are often treated with uniform therapies. Unfortunately, such an approach does not take into account that different combinations of symptoms and comorbidities may result from different pathological (e.g., environmental, genetic, dietary, etc.) factors, which require specific and individualised therapeutic strategies. In this opinion paper, we aim to put forward a more differentiated, systems medicine approach to disease and patient treatment. To elaborate on this concept, we focus on the interplay of tinnitus, depression, and chronic pain. In our view, these conditions can be characterised by a variety of phenotypes composed of variable sets of symptoms and biomarkers, rather than distinct disease entities. The knowledge of the interplay of such symptoms and biomarkers will provide the key to a deeper, mechanistic understanding of disease pathologies. This paves the way for prediction and prevention of disease pathways, including more personalised and effective treatment strategies.
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Germany (DE)How to cite
APA:
Mazurek, B., Rose, M., Schulze, H., & Dobel, C. (2022). Systems Medicine Approach for Tinnitus with Comorbid Disorders. Nutrients, 14(20). https://dx.doi.org/10.3390/nu14204320
MLA:
Mazurek, Birgit, et al. "Systems Medicine Approach for Tinnitus with Comorbid Disorders." Nutrients 14.20 (2022).
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