Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites

Munir A, Marovic D, Nogueira LP, Simm R, Naemi AO, Landro SM, Helgerud M, Zheng K, Par M, Taubock TT, Attin T, Tarle Z, Boccaccini AR, Haugen HJ (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Pharmaceutics MDPI

Book Volume: 14

Article Number: 2241

Journal Issue: 10

DOI: 10.3390/pharmaceutics14102241

Abstract

Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant. Surface micromorphology and elemental analysis were performed to evaluate the homogeneous distribution of filler particles. The study investigated the effects of Cu-MBGN on the degree of conversion, polymerization shrinkage, porosity, ion release and anti-bacterial activity on S. mutans and A. naeslundii. Experimental materials containing Cu-MBGN showed a dose-dependent Cu release with an initial burst and a further increase after 28 days. The composite containing 10% Cu-MBGN had the best anti-bacterial effect on S. mutans, as evidenced by the lowest adherence of free-floating bacteria and biofilm formation. In contrast, the 45S5-containing materials had the highest S. mutans adherence. Ca release was highest in the bioactive control containing 15% 45S5, which correlated with the highest number of open porosities on the surface. Polymerization shrinkage was similar for all tested materials, ranging from 3.8 to 4.2%, while the degree of conversion was lower for Cu-MBGN materials. Cu-MBGN composites showed better anti-bacterial properties than composites with 45S5 BG.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

University of Oslo NO Norway (NO) University of Zagreb / Sveučilište u Zagrebu HR Croatia (HR) Nanjing Medical University / 南京医科大学 CN China (CN) University of Zurich / Universität Zürich (UZH) CH Switzerland (CH)

How to cite

APA:

Munir, A., Marovic, D., Nogueira, L.P., Simm, R., Naemi, A.-O., Landro, S.M.,... Haugen, H.J. (2022). Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites. Pharmaceutics, 14(10). https://dx.doi.org/10.3390/pharmaceutics14102241

MLA:

Munir, Arooj, et al. "Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites." Pharmaceutics 14.10 (2022).

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