Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma

Mikuteit M, Zschäbitz S, Erlmeier M, Autenrieth M, Weichert W, Hartmann A, Steffens S, Erlmeier F (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Oncology Karger

Book Volume: 100

Pages Range: 536-541

Journal Issue: 10

DOI: 10.1159/000525601

Abstract

BACKGROUND: Overexpression of tumor-associated growth arrest-specific protein 6 (Gas6) is found in many tumor entities. The prognostic value of Gas6 in renal cell carcinoma (RCC), especially in non-clear cell RCC, is still unclear. AIM: The aim of the study was to evaluate the prognostic impact of Gas6 expression in a large cohort of patients with chromophobe RCC (chRCC). MATERIAL AND METHODS: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Gas6 expression by immunohistochemistry. RESULTS: Eighty-one chRCC patients were eligible for analysis; of these, 24 (29.6%) patients were positive for Gas6. No significant associations were found for Gas6 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Gas6- compared to Gas6+ (89.6% vs. 100.0%; p = 0.288) tumors. CONCLUSION: In chRCC, Gas6 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Franziska Erlmeier Institute of Pathology

Involved external institutions

Klinikum rechts der Isar DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Mikuteit, M., Zschäbitz, S., Erlmeier, M., Autenrieth, M., Weichert, W., Hartmann, A.,... Erlmeier, F. (2022). Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma. Oncology, 100(10), 536-541. https://dx.doi.org/10.1159/000525601

MLA:

Mikuteit, Marie, et al. "Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma." Oncology 100.10 (2022): 536-541.

BibTeX: Download