Schmalzl A, Leupold T, Kreiß L, Waldner M, Schürmann S, Neurath M, Becker C, Wirtz S (2022)
Publication Type: Journal article
Publication year: 2022
Book Volume: 13
Article Number: 5730
Journal Issue: 1
DOI: 10.1038/s41467-022-33326-5
Group 3 innate lymphoid cells (ILC3s) are crucial mediators of immunity and epithelial barrier function during immune responses against extracellular bacteria. Here, we identify Interferon regulatory factor 1 (IRF-1), a transcription factor previously associated with type 1 immunity, as an essential regulator of intestinal ILC3 accumulation and effector cytokine production. We demonstrate that IRF-1 is upregulated in the context of infection with the enteropathogen Citrobacter rodentium and that its presence is central for anatomical containment and prevention of pathogen dissemination. We furthermore show that IRF-1 is required in order for intestinal ILC3s to produce large amounts of the protective effector cytokine IL-22 early in the course of infection. On a molecular level, our data indicate that IRF-1 controls ILC3 numbers and their activation by direct transcriptional regulation of the IL-12Rβ1 chain, thereby allowing ILCs to physiologically respond to IL-23 stimulation.
APA:
Schmalzl, A., Leupold, T., Kreiß, L., Waldner, M., Schürmann, S., Neurath, M.,... Wirtz, S. (2022). Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33326-5
MLA:
Schmalzl, Angelika, et al. "Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection." Nature Communications 13.1 (2022).
BibTeX: Download