Response to Oswald et al.: ST6Gal1 in plasma is dispensable for IgG sialylation

Werner A, Nimmerjahn F (2022)

Publication Type: Journal article, Letter

Publication year: 2022

Journal

Glycobiology Oxford University Press (OUP): Policy B - Oxford Open Option B

DOI: 10.1093/glycob/cwac055

Abstract

The presence or absence of terminal sialic acid residues in the sugar moiety attached to the Fc-domain of IgG molecules modulates IgG activity and is associated with autoimmune or infection related inflammation. In a recent paper, Oswald and colleagues suggest that IgG sialylation may occur post IgG secretion from plasma cells, which would be a major issue for therapeutic antibodies injected into patients. In contrast, we argue that previous work rather demonstrates that IgG sialylation occurs within B cells and that the experimental system used by the authors is not suitable to address this critical question.

Authors with CRIS profile

Anja Werner Lehrstuhl für Genetik Falk Nimmerjahn Lehrstuhl für Genetik

How to cite

APA:

Werner, A., & Nimmerjahn, F. (2022). Response to Oswald et al.: ST6Gal1 in plasma is dispensable for IgG sialylation. Glycobiology. https://dx.doi.org/10.1093/glycob/cwac055

MLA:

Werner, Anja, and Falk Nimmerjahn. "Response to Oswald et al.: ST6Gal1 in plasma is dispensable for IgG sialylation." Glycobiology (2022).

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