Impaired B Cell Expression of the Inhibitory Fcγ Receptor IIB in Myasthenia Gravis

Keller CW, Chuquisana O, Derdelinckx J, Gross CC, Berger K, Robinson J, Nimmerjahn F, Wiendl H, Willcox N, Lünemann JD (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Annals of Neurology Wiley-Blackwell

DOI: 10.1002/ana.26507

Abstract

Myasthenia gravis (MG) is an autoimmune disease in which pathogenic immunoglobulin G antibodies bind to acetylcholine receptors (or to functionally related molecules at the neuromuscular junction). B cell expression of the inhibitory immunoglobulin G receptor, Fc-gamma receptor (FcγR) IIB, maintains peripheral immune tolerance, and its absence renders B cells hyperresponsive to autoantigen. Here, we report that FcγRIIB expression levels are substantially reduced in B lineage cells derived from immunotherapy-naïve patients with acetylcholine receptor antibody-positive early-onset MG. In contrast, genetic variants associated with impaired FcγRIIB expression are not enriched in MG, indicating post-transcriptional dysregulation. FcγR-targeted therapies could have therapeutic benefits in MG. ANN NEUROL 2022.

Authors with CRIS profile

Falk Nimmerjahn Lehrstuhl für Genetik

Involved external institutions

Hospital Network Antwerp / Ziekenhuis Netwerk Antwerpen (ZNA) BE Belgium (BE) Westfälische Wilhelms-Universität (WWU) Münster DE Germany (DE) Universitätsklinikum Münster DE Germany (DE) University of Leeds GB United Kingdom (GB) MRC Weatherall Institute Of Molecular Medicine GB United Kingdom (GB)

How to cite

APA:

Keller, C.W., Chuquisana, O., Derdelinckx, J., Gross, C.C., Berger, K., Robinson, J.,... Lünemann, J.D. (2022). Impaired B Cell Expression of the Inhibitory Fcγ Receptor IIB in Myasthenia Gravis. Annals of Neurology. https://dx.doi.org/10.1002/ana.26507

MLA:

Keller, Christian W., et al. "Impaired B Cell Expression of the Inhibitory Fcγ Receptor IIB in Myasthenia Gravis." Annals of Neurology (2022).

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