Vestibular Schwannoma Volume and Tumor Growth Correlates with Macrophage Marker Expression

Leisz S, Klause CH, Dos Santos TV, Haenel P, Scheer M, Simmermacher S, Mawrin C, Strauss C, Scheller C, Rampp S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Cancers MDPI

Book Volume: 14

Article Number: 4429

Journal Issue: 18

DOI: 10.3390/cancers14184429

Abstract

Vestibular schwannoma is the most common benign tumor of the cerebellopontine angle and originates from Schwann cells surrounding the vestibulocochlear nerve. Since the size of the VS varies widely, affected patients suffer from symptoms of varying severity. It is often difficult to determine the optimal time for therapy, due to the unpredictability of the growth rate. Despite many investigations on influencing factors, no mechanism responsible for the increase in the growth rate of certain VS has been identified so far. Therefore, the present study investigates the influence of the seven markers: Ki-67, cyclooxygenase 2 (COX2), vascular endothelial growth factor (VEGF), macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), CD163, and CD68 on tumor progression and tumor size in a cohort of 173 VS. The markers were determined by quantitative PCR and correlated with tumor volume and VS growth rate. The analysis showed a significantly negative correlation of the Ki-67, COX2, and VEGF on tumor volume. Moreover, with a higher volume of VS, the expression of the macrophage markers CD68, CD163, and GM-CSF increased significantly. Our results suggest that the increase in VS size is not primarily due to Schwann cell growth but to an infiltration of macrophages. This may have an impact on non-invasive therapy to preserve the hearing function of affected patients.

Authors with CRIS profile

Stefan Rampp Department of Neurosurgery

Involved external institutions

Martin-Luther-Universität Halle-Wittenberg (MLU) DE Germany (DE) Otto-von-Guericke-Universität Magdeburg DE Germany (DE)

How to cite

APA:

Leisz, S., Klause, C.H., Dos Santos, T.V., Haenel, P., Scheer, M., Simmermacher, S.,... Rampp, S. (2022). Vestibular Schwannoma Volume and Tumor Growth Correlates with Macrophage Marker Expression. Cancers, 14(18). https://dx.doi.org/10.3390/cancers14184429

MLA:

Leisz, Sandra, et al. "Vestibular Schwannoma Volume and Tumor Growth Correlates with Macrophage Marker Expression." Cancers 14.18 (2022).

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