When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron

Schlachetzki JCM, Toda T, Mertens J (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Experimental Gerontology Elsevier

Book Volume: 133

Article Number: 110876

DOI: 10.1016/j.exger.2020.110876

Abstract

The human brain is affected by cellular aging. Neurons are primarily generated during embryogenesis and early life with a limited capacity for renewal and replacement, making them some of the oldest cells in the human body. Our present understanding of neurodegenerative diseases points towards advanced neuronal age as a prerequisite for the development of these disorders. While significant progress has been made in understanding the relationship between aging and neurological disease, it will be essential to delve further into the molecular mechanisms of neuronal aging in order to develop therapeutic interventions targeting age-related brain dysfunction. In this mini review, we highlight recent findings on the relationship between the aging of nuclear structures and changes in the epigenetic landscape during neuronal aging and disease.

Authors with CRIS profile

Tomohisa Toda

Involved external institutions

University of California, San Diego US United States (USA) (US) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) DE Germany (DE) Leopold-Franzens-Universität Innsbruck / University of Innsbruck AT Austria (AT)

How to cite

APA:

Schlachetzki, J.C.M., Toda, T., & Mertens, J. (2020). When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron. Experimental Gerontology, 133. https://dx.doi.org/10.1016/j.exger.2020.110876

MLA:

Schlachetzki, Johannes C. M., Tomohisa Toda, and Jerome Mertens. "When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron." Experimental Gerontology 133 (2020).

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