Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 40
Article Number: e105819
Journal Issue: 3
Abstract
Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age-dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age-related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age-related anxiety-like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.
Authors with CRIS profile
Involved external institutions
Salk Institute for Biological Studies
United States (USA) (US)
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Germany (DE)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Germany (DE)
United States (USA) (US)
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
Germany (DE)
Max-Planck-Institut für molekulare Zellbiologie und Genetik / Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Germany (DE)
How to cite
APA:
Bedrosian, T.A., Houtman, J., Eguiguren, J.S., Ghassemzadeh, S., Rund, N., Novaresi, N.M.,... Toda, T. (2021). Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO Journal, 40(3). https://doi.org/10.15252/embj.2020105819
MLA:
Bedrosian, Tracy A., et al. "Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis." EMBO Journal 40.3 (2021).
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