A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy
Buettner FA, Winter S, Stuehler V, Rausch S, Hennenlotter J, Füssel S, Zastrow S, Meinhardt M, Toma M, Jeronimo C, Henrique R, Miranda-Goncalves V, Kroeger N, Ribback S, Hartmann A, Agaimy A, Stoehr C, Polifka I, Fend F, Scharpf M, Comperat E, Wasinger G, Moch H, Stenzl A, Gerlinger M, Bedke J, Schwab M, Schaeffeler E (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 14
Journal Issue: 1
DOI: 10.1186/s13073-022-01105-y
Abstract
Background: Renal cell carcinoma (RCC) is a heterogeneous disease comprising histologically defined subtypes. For therapy selection, precise subtype identification and individualized prognosis are mandatory, but currently limited. Our aim was to refine subtyping and outcome prediction across main subtypes, assuming that a tumor is composed of molecular features present in distinct pathological subtypes.
Authors with CRIS profile
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Abbas Agaimy
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Iris Polifka
Institute of Pathology
Involved external institutions
Instituto Português de Oncologia Francisco Gentil (IPO) / Portuguese Oncology Institute
Portugal (PT)
Universitätsklinikum Tübingen
Germany (DE)
Technische Universität Dresden
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Germany (DE)
Robert-Bosch-Krankenhaus
Germany (DE)
Queen Mary, University of London
United Kingdom (GB)
University of Zurich / Universität Zürich (UZH)
Switzerland (CH)
Universität Greifswald
Germany (DE)
Universitätsklinikum Carl Gustav Carus Dresden
Germany (DE)
Portugal (PT)
Universitätsklinikum Tübingen
Germany (DE)
Technische Universität Dresden
Germany (DE)
Medizinische Universität Wien
Austria (AT)
Universitätsmedizin Greifswald / Universitätsklinikum Greifswald
Germany (DE)
Robert-Bosch-Krankenhaus
Germany (DE)
Queen Mary, University of London
United Kingdom (GB)
University of Zurich / Universität Zürich (UZH)
Switzerland (CH)
Universität Greifswald
Germany (DE)
Universitätsklinikum Carl Gustav Carus Dresden
Germany (DE)
How to cite
APA:
Buettner, F.A., Winter, S., Stuehler, V., Rausch, S., Hennenlotter, J., Füssel, S.,... Schaeffeler, E. (2022). A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy. Genome Medicine, 14(1). https://dx.doi.org/10.1186/s13073-022-01105-y
MLA:
Buettner, Florian A., et al. "A novel molecular signature identifies mixed subtypes in renal cell carcinoma with poor prognosis and independent response to immunotherapy." Genome Medicine 14.1 (2022).
BibTeX: Download