A Novel IMFET Biosensor Strategy for Interleukin-10 Quantification for Early Screening Heart Failure Disease in Saliva

Ben Halima H, Bellagambi FG, Hangouet M, Alcacer A, Pfeiffer N, Heuberger A, Zine N, Bausells J, Errachid A (2022)

Publication Type: Journal article

Publication year: 2022

Journal

DOI: 10.1002/elan.202200141

Abstract

We propose a salivary Interleukin-10 detection strategy as part of an easily integrable Lab-on-Chip and Point-of-Care IMFET for multi-detection Heart Failure (HF) biomarkers. Our developed IMFET showed good linearity between increasing IL-10 concentration and the charge transfer resistance in both standard solutions and real saliva samples with a LOD of 0.02 pg mL⁻¹. Moreover, the cross-selectivity study showed that the developed IMFET was highly selective towards IL-10 against other HF biomarkers. The precision of our IMFET was also evaluated, and the difference between the determined IL-10 concentration using the standard addition method and its expected one is<20 %.

Authors with CRIS profile

Albert Heuberger Lehrstuhl für Informationstechnik mit dem Schwerpunkt Kommunikationselektronik (Stiftungslehrstuhl)

Involved external institutions

Université Claude Bernard Lyon 1 (UCB)

France (FR) National Center for Scientific Research / Centre national de la recherche scientifique (CNRS)

France (FR) Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC)

Spain (ES) Fraunhofer-Institut für Integrierte Schaltungen (IIS)

Germany (DE)

How to cite

APA:

Ben Halima, H., Bellagambi, F.G., Hangouet, M., Alcacer, A., Pfeiffer, N., Heuberger, A.,... Errachid, A. (2022). A Novel IMFET Biosensor Strategy for Interleukin-10 Quantification for Early Screening Heart Failure Disease in Saliva. Electroanalysis. https://dx.doi.org/10.1002/elan.202200141

MLA:

Ben Halima, Hamdi, et al. "A Novel IMFET Biosensor Strategy for Interleukin-10 Quantification for Early Screening Heart Failure Disease in Saliva." Electroanalysis (2022).

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