Resection of dominant fusiform gyrus is associated with decline of naming function when temporal lobe epilepsy manifests after the age of five: A voxel-based lesion-symptom mapping study
Reindl C, Allgäuer A, Kleiser B, Onugoren MD, Lang J, Welte T, Stritzelberger J, Winder K, Schwarz M, Gollwitzer S, Trollmann R, Rösch J, Dörfler A, Rössler K, Brandner S, Madžar D, Seifert F, Rampp S, Hamer H, Walther K (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 35
Article Number: 103129
DOI: 10.1016/j.nicl.2022.103129
Abstract
Objective: To determine patients’ characteristics and regions in the temporal lobe where resections lead to a decline in picture naming. Methods: 311 patients with left hemispheric dominance for language were included who underwent epilepsy surgery at the Epilepsy Center of Erlangen and whose picture naming scores (Boston Naming Test, BNT) were available preoperatively and 6-months postoperatively. Surgical lesions were mapped to an averaged template based on preoperative and postoperative MRI using voxel-based lesion-symptom mapping (VBLSM). Postoperative brain shifts were corrected. The relationship between lesioned brain areas and the presence of a postoperative naming decline was examined voxel-wise while controlling for effects of overall lesion size at first in the total cohort and then restricted to temporal lobe resections. Results: In VBLSM in the total sample, a decline in BNT score was significantly related to left temporal surgery. When only considering patients with left temporal lobe resections (n = 121), 40 (33.1%) significantly worsened in BNT postoperatively. VBLSM including all patients with left temporal resections generated no significant results within the temporal lobe. However, naming decline of patients with epilepsy onset after 5 years of age was significantly associated with resections in the left inferior temporal (extent of BNT decline range: 10.8− 14.4%) and fusiform gyrus (decline range: 12.1−18.4%). Significance: Resections in the posterior part of the dominant fusiform and inferior temporal gyrus was associated with a risk of deterioration in naming performance at six months after surgery in patients with epilepsy onset after 5 years of age but not with earlier epilepsy onset.
Authors with CRIS profile
Caroline Reindl
Department of Neurology
Andrea Allgäuer
Department of Medicine 5 – Haematology and Oncology
Benedict Kleiser
Professur für Epileptologie
Johannes Lang
Department of Psychiatry and Psychotherapy
Tamara Welte
Department of Neurology
Jenny Stritzelberger
Department of Radiation Oncology
Klemens Winder
Department of Neurology
Michael Schwarz
Department of Neurology
Regina Trollmann
Professur für Kinder- u. Jugendmedizin Schwerpunkt Neuropädiatrie
Julie Rösch
Department of Neuroradiology
Arnd Dörfler
Department of Neuroradiology
Sebastian Brandner
Department of Neurosurgery
Dominik Madzar
Lehrstuhl für Neurologie
Frank Seifert
Lehrstuhl für Neurologie
Stefan Rampp
Department of Neurosurgery
Hajo Hamer
Professur für Epileptologie
Involved external institutions
Austria (AT)How to cite
APA:
Reindl, C., Allgäuer, A., Kleiser, B., Onugoren, M.D., Lang, J., Welte, T.,... Walther, K. (2022). Resection of dominant fusiform gyrus is associated with decline of naming function when temporal lobe epilepsy manifests after the age of five: A voxel-based lesion-symptom mapping study. NeuroImage: Clinical, 35. https://dx.doi.org/10.1016/j.nicl.2022.103129
MLA:
Reindl, Caroline, et al. "Resection of dominant fusiform gyrus is associated with decline of naming function when temporal lobe epilepsy manifests after the age of five: A voxel-based lesion-symptom mapping study." NeuroImage: Clinical 35 (2022).
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