Small-Molecular-Weight Additives Modulate Calcification by Interacting with Prenucleation Clusters on the Molecular Level

Duchstein P, Schodder P, Leupold S, Dao TQN, Kababya S, Cicconi MR, de Ligny D, Pipich V, Eike D, Schmidt A, Zahn D, Wolf S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Angewandte Chemie International Edition Wiley

DOI: 10.1002/anie.202208475

Abstract

Small-molecular-weight (MW) additives can strongly impact amorphous calcium carbonate (ACC), playing an elusive role in biogenic, geologic, and industrial calcification. Here, we present molecular mechanisms by which these additives regulate stability and composition of both CaCO3 solutions and solid ACC. Potent antiscalants inhibit ACC precipitation by interacting with prenucleation clusters (PNCs); they specifically trigger and integrate into PNCs or feed PNC growth actively. Only PNC-interacting additives are traceable in ACC, considerably stabilizing it against crystallization. The selective incorporation of potent additives in PNCs is a reliable chemical label that provides conclusive chemical evidence that ACC is a molecular PNC-derived precipitate. Our results reveal additive-cluster interactions beyond established mechanistic conceptions. They reassess the role of small-MW molecules in crystallization and biomineralization while breaking grounds for new sustainable antiscalants.

Authors with CRIS profile

Patrick Duchstein Computer-Chemie-Centrum (CCC) Philipp Schodder Lehrstuhl für Glas und Keramik (WW3) Simon Leupold Lehrstuhl für Glas und Keramik (WW3) Thi Quynh Nhi Dao Lehrstuhl für Glas und Keramik (WW3) Maria Rita Cicconi Lehrstuhl für Glas und Keramik (WW3) Dominique de Ligny Professur für Werkstoffwissenschaften (Glas und Keramik) Dirk Zahn Professur für Theoretische Chemie Stephan Wolf Lehrstuhl für Glas und Keramik (WW3)

Involved external institutions

Technion - Israel Institute of Technology IL Israel (IL) Forschungszentrum Jülich / Research Centre Jülich (FZJ) DE Germany (DE) Procter & Gamble US United States (USA) (US)

How to cite

APA:

Duchstein, P., Schodder, P., Leupold, S., Dao, T.Q.N., Kababya, S., Cicconi, M.R.,... Wolf, S. (2022). Small-Molecular-Weight Additives Modulate Calcification by Interacting with Prenucleation Clusters on the Molecular Level. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202208475

MLA:

Duchstein, Patrick, et al. "Small-Molecular-Weight Additives Modulate Calcification by Interacting with Prenucleation Clusters on the Molecular Level." Angewandte Chemie International Edition (2022).

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