Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy

Prasuhn J, Göttlich M, Grosser SS, Reuther K, Ebeling B, Bodemann C, Hanssen H, Nagel AM, Brüggemann N (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Biomedicines MDPI AG

Book Volume: 10

Journal Issue: 7

DOI: 10.3390/biomedicines10071728

Abstract

Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (Na-23-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) Na-23-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. Na-23-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP.

Authors with CRIS profile

Armin Michael Nagel Professur für metabolische und funktionelle MR-Bildgebung

Involved external institutions

Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Universität zu Lübeck DE Germany (DE)

How to cite

APA:

Prasuhn, J., Göttlich, M., Grosser, S.S., Reuther, K., Ebeling, B., Bodemann, C.,... Brüggemann, N. (2022). Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy. Biomedicines, 10(7). https://dx.doi.org/10.3390/biomedicines10071728

MLA:

Prasuhn, Jannik, et al. "Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy." Biomedicines 10.7 (2022).

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